Cédric Clouchoux

TL;DR: In the HLHS fetus, local cortical folding delays were detected as early as 25 weeks and appear to precede volumetric brain growth disturbances, which may be an early marker of elevated risk for third trimester brain growth failure.

TL;DR: The in vivo fetal cortical folding pattern in healthy fetuses between 25 and 35 weeks gestational age is investigated using 3-D reconstructed fetal cortical surfaces using a robust feature extraction algorithm applied directly on the cortical surface, providing an explicit delineation of the sulcal pattern during fetal brain development.

TL;DR: The availability and ongoing validation of normative Fetal magnetic resonance imaging trajectories will provide important tools for early detection of impaired fetal brain growth upon which to manage high-risk pregnancies.

TL;DR: The ongoing refinement of these magnetic resonance imaging techniques will undoubtedly lead to the development of cornerstone biomarkers that will provide healthcare caregivers with vital, and currently lacking, information upon which to counsel parents effectively, and base rational decisions regarding the timing and type of novel medical and surgical interventions currently on the horizon.

TL;DR: A mathematical framework for the construction of an unbiased deformable spatiotemporal atlas of the fetal brain MRI and compared it to alternative configurations in terms of similarity metrics and deformation models indicates that symmetric diffeomorphic deformable registration with cross correlation similarity metric outperforms other configurations in this application.