Delayed Cortical Development in Fetuses with Complex Congenital Heart Disease
Cédric Clouchoux,A.J. du Plessis,Marine Bouyssi-Kobar,Wayne Tworetzky,Wayne Tworetzky,Doff B. McElhinney,Doff B. McElhinney,David W. Brown,David W. Brown,Ali Gholipour,D. Kudelski,Simon K. Warfield,Robert McCarter,Richard L. Robertson,Richard L. Robertson,Alan C. Evans,Jane W. Newburger,Jane W. Newburger,Catherine Limperopoulos +18 more
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TLDR
In the HLHS fetus, local cortical folding delays were detected as early as 25 weeks and appear to precede volumetric brain growth disturbances, which may be an early marker of elevated risk for third trimester brain growth failure.Abstract:
Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body of evidence suggests that neurologic dysfunction may be present in a significant proportion of this high-risk population in the early newborn period prior to surgical interventions. We recently provided the first evidence that brain growth impairment in fetuses with complex CHD has its origins in utero. Here, we extend these observations by characterizing global and regional brain development in fetuses with hypoplastic left heart syndrome (HLHS), one of the most severe forms of CHD. Using advanced magnetic resonance imaging techniques, we compared in vivo brain growth in 18 fetuses with HLHS and 30 control fetuses from 25.4-37.0 weeks of gestation. Our findings demonstrate a progressive third trimester fall-off in cortical gray and white matter volumes (P < 0.001), and subcortical gray matter (P < 0.05) in fetuses with HLHS. Significant delays in cortical gyrification were also evident in HLHS fetuses (P < 0.001). In the HLHS fetus, local cortical folding delays were detected as early as 25 weeks in the frontal, parietal, calcarine, temporal, and collateral regions and appear to precede volumetric brain growth disturbances, which may be an early marker of elevated risk for third trimester brain growth failure.read more
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References
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A nonparametric method for automatic correction of intensity nonuniformity in MRI data
TL;DR: A novel approach to correcting for intensity nonuniformity in magnetic resonance (MR) data is described that achieves high performance without requiring a model of the tissue classes present, and is applied at an early stage in an automated data analysis, before a tissue model is available.
Journal Article
人唾液天疱疮抗原的纯化
TL;DR: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation, move it to a nose cone for hair removal using cream and reduce anesthesia to maintain proper heart rate.
Book
The attentive brain.
TL;DR: In this article, the authors introduce the concept of attention and propose methods for its application in the development and pathologies of pathologies in the biomedical domain, focusing on the brain.