Cédric Malicet

TL;DR: The stress-regulated protein p8 is identified as an essential mediator of cannabinoid antitumoral action and it is shown that p8 upregulation is dependent on de novo-synthesized ceramide and mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3.

TL;DR: The results strongly suggest that the antiapoptotic response of HeLa cells upon staurosporine treatment requires expression of both p8 and ProTα.

TL;DR: It is suggested that a large part of gemcitabine-induced apoptosis results from the inhibition of the constitutive antiapoptotic activity of p8, and targeting the p8-associated pathway could be a new adjuvant therapy improving the response of patients with pancreatic cancer to gem citabine treatment.

TL;DR: A first catalog of genes whose expression is altered upon fibroblast transformation by rasV12/E1A is established, suggesting that, in human cancers, proteases, protease inhibitors and angiogenic factors could be regulated through a mechanism disconnected from ras activation.

TL;DR: The results suggest that p8 belongs to a pathway regulating the growth of pancreatic cancer cells, which is induced through pathways involved in growth inhibition and repressed by factors that promote cell growth.