C
Cristina Blázquez
Researcher at Complutense University of Madrid
Publications - 41
Citations - 5802
Cristina Blázquez is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 31, co-authored 39 publications receiving 5300 citations.
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Journal ArticleDOI
Prevention of Alzheimer's Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation
Belén G. Ramírez,Cristina Blázquez,Teresa Gómez del Pulgar,Manuel Guzmán,María L. de Ceballos +4 more
TL;DR: It is shown that senile plaques in AD patients express cannabinoid receptors CB1 and CB2, together with markers of microglial activation, and that CB1-positive neurons, present in high numbers in control cases, are greatly reduced in areas of microgoo activation.
Journal ArticleDOI
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
María Salazar,Arkaitz Carracedo,Íñigo J. Salanueva,Sonia Hernández-Tiedra,Mar Lorente,Ainara Egia,Patricia Vázquez,Cristina Blázquez,Sofia Torres,Stéphane Garcia,Jonathan Nowak,Gian Maria Fimia,Mauro Piacentini,Francesco Cecconi,Pier Paolo Pandolfi,Luis González-Feria,Juan L. Iovanna,Manuel Guzmán,Patricia Boya,Guillermo Velasco +19 more
TL;DR: It is demonstrated that delta(9)-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy and evidence is provided that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.
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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
M. Llanos Casanova,Cristina Blázquez,Jesús Martínez-Palacio,Concepción Villanueva,M. Jesús Fernández-Aceñero,John W. Huffman,José L. Jorcano,Manuel Guzmán +7 more
TL;DR: It is shown that the CB(1) and theCB(2) receptor are expressed in normal skin and skin tumors of mice and humans and support a new therapeutic approach for the treatment of skin tumors.
Journal ArticleDOI
The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
Arkaitz Carracedo,Mar Lorente,Ainara Egia,Cristina Blázquez,Stéphane Garcia,Valentin Giroux,Cédric Malicet,Raquel Villuendas,Meritxell Gironella,Luis González-Feria,Miguel A. Piris,Juan L. Iovanna,Manuel Guzmán,Guillermo Velasco +13 more
TL;DR: The stress-regulated protein p8 is identified as an essential mediator of cannabinoid antitumoral action and it is shown that p8 upregulation is dependent on de novo-synthesized ceramide and mediates its apoptotic effect via upregulation of the endoplasmic reticulum stress-related genes ATF-4, CHOP, and TRB3.
Journal ArticleDOI
A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
Manuel Guzmán,M J Duarte,Cristina Blázquez,J Ravina,Rosa M,Ismael Galve-Roperh,Cristina Sánchez,Guillermo Velasco,Luis González-Feria +8 more
TL;DR: The fair safety profile of THC, together with its possible antiproliferative action on tumour cells reported here and in other studies, may set the basis for future trials aimed at evaluating the potential antitumoral activity of cannabinoids.