C
Celine Bauwens
Researcher at University of Toronto
Publications - 11
Citations - 2252
Celine Bauwens is an academic researcher from University of Toronto. The author has contributed to research in topics: Embryonic stem cell & Embryoid body. The author has an hindex of 8, co-authored 11 publications receiving 2159 citations. Previous affiliations of Celine Bauwens include University Health Network.
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Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates.
TL;DR: It is demonstrated that hESC input composition and inductive environment could be manipulated to form large numbers of well-defined aggregates exhibiting multi-lineage differentiation and substantially improved self-organization from single-cell suspensions.
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Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories.
Celine Bauwens,Raheem Peerani,Sylvia Niebruegge,Kimberly A. Woodhouse,Eugenia Kumacheva,Mansoor Husain,Peter W. Zandstra +6 more
TL;DR: It is demonstrated that heterogeneity in hESC colony and aggregate size produces subsets of appropriate conditions for differentiation into specific cell types, and suggested that the local microenvironment modulates endogenous parameters that can be used to influence pluripotent cell differentiation trajectories.
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Niche-mediated control of human embryonic stem cell self-renewal and differentiation.
Raheem Peerani,Balaji M. Rao,Celine Bauwens,Ting Yin,Geoffrey A. Wood,Andras Nagy,Andras Nagy,Eugenia Kumacheva,Peter W. Zandstra +8 more
TL;DR: It is demonstrated that the rate and trajectory of hESC differentiation can be controlled by engineering hESCs niche properties and a role for Smad1 is illustrated, for the first time, in the integration of spatial information and in the niche‐size‐dependent control of h ESC self‐renewal and differentiation.
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Scalable production of embryonic stem cell-derived cardiomyocytes.
Peter W. Zandstra,Celine Bauwens,Ting Yin,Q. Liu,Hilmar Schiller,Robert Zweigerdt,Kishore B.S. Pasumarthi,Loren J. Field +7 more
TL;DR: The results demonstrate the feasibility of large-scale production of viable, ES cell-derived cardiomyocytes for tissue engineering and/or implantation, an approach that should be transferable to other ES cell derived lineages, as well as to adult stem cells with in vitroCardiomyogenic activity.
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Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor.
Sylvia Niebruegge,Celine Bauwens,Raheem Peerani,Nimalan Thavandiran,Stéphane Massé,Elias Sevaptisidis,K. Nanthakumar,Kim Woodhouse,Kim Woodhouse,Mansoor Husain,Mansoor Husain,Eugenia Kumacheva,Peter W. Zandstra +12 more
TL;DR: This study provides an important foundation towards the robust generation of clinically relevant numbers of hESC derived cells by demonstrating the beneficial effects of stirred bioreactor culture, aggregate size‐control and hypoxia on both cell growth and cell differentiation towards cardiomyocytes.