L
Loren J. Field
Researcher at Indiana University
Publications - 179
Citations - 20267
Loren J. Field is an academic researcher from Indiana University. The author has contributed to research in topics: Myocyte & Stem cell. The author has an hindex of 65, co-authored 175 publications receiving 19297 citations. Previous affiliations of Loren J. Field include Rhode Island Hospital & Riley Hospital for Children.
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Journal ArticleDOI
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
Charles E. Murry,Mark H. Soonpaa,Hans Reinecke,Hidehiro Nakajima,Hisako O. Nakajima,Michael Rubart,Kishore B.S. Pasumarthi,Kishore B.S. Pasumarthi,Jitka A. I. Virag,Stephen H. Bartelmez,Veronica Poppa,Gillian Bradford,Joshua D. Dowell,David A. Williams,David A. Williams,Loren J. Field +15 more
TL;DR: Results indicate that haematopoietic stem cells do not readily acquire a cardiac phenotype, and raise a cautionary note for clinical studies of infarct repair.
Journal ArticleDOI
Human cardiovascular progenitor cells develop from a KDR + embryonic-stem-cell-derived population
Lei Yang,Mark H. Soonpaa,Eric Adler,Torsten K. Roepke,Steven J. Kattman,Marion Kennedy,Els Henckaerts,Kristina Bonham,Geoffrey W. Abbott,R. Michael Linden,R. Michael Linden,Loren J. Field,Gordon Keller,Gordon Keller +13 more
TL;DR: Analysis of the development of the cardiovascular lineages in human embryonic stem cell differentiation cultures identifies a human cardiovascular progenitor that defines one of the earliest stages of human cardiac development.
Journal ArticleDOI
Genetically selected cardiomyocytes from differentiating embronic stem cells form stable intracardiac grafts.
TL;DR: A simple genetic manipulation can be used to select essentially pure cultures of cardiomyocytes from differentiating ES cells that are suitable for the formation of intracardiac grafts, and should be applicable to all ES-derived cell lineages.
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Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy
Howard A. Rockman,Robert S. Ross,Adrienne N. Harris,Kirk U. Knowlton,Mark E. Steinhelper,Loren J. Field,John Ross,Kenneth R. Chien +7 more
TL;DR: Evidence is provided that atrial-specific and inducible expression of the atrial natriuretic factor gene can be segregated, suggesting that a distinct set of regulatory cis sequences may mediate the up-regulation of the ANF gene during in vivo pressure overload hypertrophy.
Journal ArticleDOI
Cardiomyocyte DNA synthesis and binucleation during murine development
TL;DR: Results suggest that cardiomyocyte reduplication ceases during late fetal life, and several candidate genes that were differentially expressed during the reduplicative and binucleation phases of carduomyocyte growth are identified.