Robert Zweigerdt

TL;DR: The generation of human iPSCs from cord blood (CB) as a juvenescent cell source is reported, showing characteristics typical of embryonic stem cells and can be differentiated into derivatives of all three germ layers, including functional cardiomyocytes.

TL;DR: Using stringent selection criteria, Chast was identified as a potential lncRNA candidate that influences cardiomyocyte hypertrophy and was discovered to be up-regulated in hypertrophic mouse hearts, which could one day be targeted with therapeutics to treat human cardiovascular diseases.

TL;DR: The results demonstrate the feasibility of large-scale production of viable, ES cell-derived cardiomyocytes for tissue engineering and/or implantation, an approach that should be transferable to other ES cell derived lineages, as well as to adult stem cells with in vitroCardiomyogenic activity.

TL;DR: Modulation of the p38MAP kinase pathway plays an essential role in early lineage determination in hESC and the efficiency of cardiomyogenesis and these findings contribute to transforming humanCardiomyocyte generation from hESc into a robust and scalable process.

TL;DR: This culture technique was successfully tested on two hiPSC clones, three hESC lines and on a nonhuman primate ESC line and does not require culture preadaptation, use of microcarriers or any other matrices.