Cesare Pellerano

TL;DR: A series of 3- and 5-methylthiophene-2-carboxaldehyde alpha-(N)-heterocyclichydrazones were synthesized and submitted to an in vitro investigation of their anticancer, anti-HIV and antimicrobial activities, where some of the newly synthesized compounds were found to possess antiproliferative properties.

TL;DR: A series of 4-quinolylhydrazones synthesized and tested against Mycobacterium tuberculosis H37Rv showed interesting antitubercular properties; two compounds (3(2) and 3(25)), identified as the most active, were tested also against MyCobacteria avium.

TL;DR: A novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed and the role played by the amino groups of homo- andheterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE was investigated.

TL;DR: The synthesis of a series of 1,2,4-triazolo[4,3-a]quinoline derivatives is described; their structures were assigned by 1H NMR and analytical data and tested in vivo for their antiinflammatory and analgesic activities.

TL;DR: Results from structure-affinity relationship studies were in full agreement with previously proposed pharmacophore models and quantitative structure-activity analysis gave further significant insight into the main molecular determinants of high benzodiazepine receptor affinity.