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Chaitanya Churi
Researcher at University of Texas MD Anderson Cancer Center
Publications - 9
Citations - 1084
Chaitanya Churi is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Gallbladder cancer & HER2/neu. The author has an hindex of 6, co-authored 9 publications receiving 861 citations.
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Journal ArticleDOI
New Routes to Targeted Therapy of Intrahepatic Cholangiocarcinomas Revealed by Next-Generation Sequencing
Jeffrey S. Ross,Jeffrey S. Ross,Kai Wang,Rami N. Al-Rohil,Janne V. Rand,David M. Jones,Hwa J. Lee,Christine E. Sheehan,Geoff Otto,Gary A. Palmer,Roman Yelensky,Doron Lipson,Deborah Morosini,Matthew J. Hawryluk,Daniel V.T. Catenacci,Vincent A. Miller,Chaitanya Churi,Siraj M. Ali,Philip J. Stephens +18 more
TL;DR: Two thirds of patients in this study harbored genomic alterations that are associated with targeted therapies and that have the potential to personalize therapy selection for to individual patients.
Journal ArticleDOI
Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic Implications
Chaitanya Churi,Rachna T. Shroff,Ying Wang,Asif Rashid,Hyunseon C. Kang,Jacqueline Weatherly,Mingxin Zuo,Ralph Zinner,David S. Hong,Funda Meric-Bernstam,Filip Janku,Christopher H. Crane,Lopa Mishra,J.N. Vauthey,Robert A. Wolff,Gordon B. Mills,Milind Javle +16 more
TL;DR: GAs in the chromatin modulating genes, BAP1 and PBRM1 were associated with bone metastases and worse survival in extrahepatic CCA, and NGS can potentially identify disease subsets with distinct prognostic and therapeutic implications.
Journal ArticleDOI
HER2/neu-directed therapy for biliary tract cancer
Milind Javle,Chaitanya Churi,Hyunseon C. Kang,Rachna T. Shroff,Filip Janku,Rakesh Surapaneni,Mingxin Zuo,Christian Daniel Barrera,Humaid O. Al-Shamsi,Sunil Krishnan,Lopa Mishra,Robert A. Wolff,Ahmed Kaseb,Melanie B. Thomas,Abby B. Siegel +14 more
TL;DR: HER2/neu blockade is a promising treatment strategy for gallbladder cancer patients with gene amplification and deserves further exploration in a multi-center study.
Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer.
TL;DR: The results indicate that HER2/neu overexpression occurred in 14% of the advanced gallbladder cancer cases, which indicates that this subgroup of patients may benefit from inhibitors of the HER2-neu pathway.
Journal ArticleDOI
Molecular characterization of gallbladder cancer using somatic mutation profiling.
Milind Javle,Asif Rashid,Chaitanya Churi,Siddhartha Kar,Mingxin Zuo,Agda Karina Eterovic,Graciela M. Nogueras-Gonzalez,Filip Janku,Rachna T. Shroff,Thomas A. Aloia,Jean Nicolas Vauthey,Steven A. Curley,Gordon B. Mills,Ivan Roa +13 more
TL;DR: Somatic mutation profiling using archival FFPE samples from gallbladder cancer is feasible and next-generation sequencing, in particular, may be a useful platform for identifying novel mutations for targeted therapy.