C
Chandrahasa R. Yellaturu
Researcher at University of Tennessee Health Science Center
Publications - 15
Citations - 1172
Chandrahasa R. Yellaturu is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Phosphorylation & Golgi apparatus. The author has an hindex of 14, co-authored 15 publications receiving 1112 citations. Previous affiliations of Chandrahasa R. Yellaturu include United States Department of Veterans Affairs & University of Tennessee.
Papers
More filters
Journal ArticleDOI
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
Rajendra Raghow,Rajendra Raghow,Chandrahasa R. Yellaturu,Xiong Deng,Xiong Deng,Edwards A. Park,Marshall B. Elam,Marshall B. Elam +7 more
TL;DR: Recent studies elucidating the transcriptional and post-transcriptional regulation of SREBP-1c through nutrition and the action of hormones, particularly insulin, and the resulting implications for dyslipidemia of obesity, metabolic syndrome and type 2 diabetes are summarized.
Journal ArticleDOI
N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.
TL;DR: It is demonstrated for the first time that PP2A mediates thiol alkylation-dependent redox regulation of Akt and cell survival and attenuated the apoptosis induced by NEM, alone or in combination with PDGF-BB.
Journal ArticleDOI
Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
Chandrahasa R. Yellaturu,Xiong Deng,Xiong Deng,Lauren M. Cagen,Henry G. Wilcox,C. M. Mansbach,Shadab A. Siddiqi,Edwards A. Park,Rajendra Raghow,Rajendra Raghow,Marshall B. Elam,Marshall B. Elam +11 more
Journal ArticleDOI
Insulin Enhances Posttranslational Processing of Nascent SREBP-1c by Promoting its Phosphorylation and Association with COPII vesicles
Chandrahasa R. Yellaturu,Xiong Deng,Lauren M. Cagen,Henry G. Wilcox,Edwards A. Park,Rajendra Raghow,Marshall B. Elam +6 more
TL;DR: It is demonstrated that insulin treatment led to enhanced post-translational processing of SREBP-1c, which was associated with phosphorylation of ER-bound nascent S REBP- 1c protein that increased affinity of the SRE BP-1C cleavage-activating protein (SCAP)-SREBP1c complex for the Sec23/24 proteins of the COPII vesicles.
Journal ArticleDOI
Insulin Enhances the Biogenesis of Nuclear Sterol Regulatory Element-binding Protein (SREBP)-1c by Posttranscriptional Down-regulation of Insig-2A and Its Dissociation from SREBP Cleavage-activating Protein (SCAP)·SREBP-1c Complex
Chandrahasa R. Yellaturu,Xiong Deng,Xiong Deng,Edwards A. Park,Rajendra Raghow,Rajendra Raghow,Marshall B. Elam,Marshall B. Elam +7 more
TL;DR: It is reported here that insulin persistently stimulates controlled proteolysis of the nascent SREBP-1c by selectively reducing the level of Insig-2a protein via accelerated degradation of its cognate mRNA.