C
Chang-Shen Lin
Researcher at Kaohsiung Medical University
Publications - 68
Citations - 6760
Chang-Shen Lin is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 22, co-authored 60 publications receiving 6079 citations. Previous affiliations of Chang-Shen Lin include Tri-Service General Hospital & National Sun Yat-sen University.
Papers
More filters
Journal ArticleDOI
Differential resistance to platinum-based drugs and 5-fluorouracil in p22phox-overexpressing oral squamous cell carcinoma: Implications of alternative treatment strategies.
Chih-Chang Hung,Chen-Yu Chien,Pei-Yu Chu,Yu-Jen Wu,Chang-Shen Lin,Chih-Jen Huang,Leong-Perng Chan,Yen-Yun Wang,Shyng-Shiou F. Yuan,Tzyh-Chyuan Hour,Jeff Yi-Fu Chen +10 more
TL;DR: It is shown that p22phox confers resistance to cisplatin in oral squamous cell carcinoma (OSCC) and whether p 22phox has clinical correlation with cis platin resistance and affects the efficacy of other platinum or nonplatinum drugs is unknown.
Journal ArticleDOI
Rapid and sensitive detection of multiple genes from the SARS-coronavirus using quantitative RT-PCR with dual systems.
Jau-Ling Huang,Hui-Tsu Lin,Yu Ming Wang,Yi-Chien Yeh,Yi-Chien Yeh,Konan Peck,Bai-Ling Lin,Huan-Wun Liu,Ann Chen,Chang-Shen Lin +9 more
TL;DR: A one‐step, real‐time quantitative reverse transcription‐polymerase chain reaction (RT‐PCR) assay was developed that could simultaneously detect nucleocapsid (N), membrane (M), and spike (S) genes of SARS‐CoV with the same PCR condition using either Applied Biosystems (ABI) Prism 7700 Sequence Detection System or Roche LightCycler.
Journal ArticleDOI
p22phox confers resistance to cisplatin, by blocking its entry into the nucleus
Chih-Chang Hung,Chen-Yu Chien,Wei Fan Chiang,Chang-Shen Lin,Tzyh-Chyuan Hour,Hau-Ren Chen,Ling-Feng Wang,Jenq-Yuh Ko,Chi-Hua Chang,Jeff Yi-Fu Chen +9 more
TL;DR: It was found that p22phox was highly expressed in CDDP-resistant OSCC specimens, and overexpression of p 22phox in OSCC cells exhibited cytoplasmic localization with enhanced perinuclear expression, consistent with the localization pattern inOSCC specimens.
Journal ArticleDOI
Enhancement of the genotoxicity of benzo[a]pyrene by arecoline through suppression of DNA repair in HEp-2 cells.
Jau-Ling Huang,H.H. Lu,Y.N. Lu,P.S. Hung,Yi-Hsiung Lin,C.C. Lin,C.C. Yang,T.Y. Wong,S.Y. Lu,Chang-Shen Lin,Chang-Shen Lin +10 more
TL;DR: Extended exposure to arecoline and BaP caused moderate-to-severe DNA damage in 60% of the cells, and Expression of the XPD helicase was transcriptionally suppressed by 1 week of treatment with BaP, revealing potential targets in the DNA repair pathway that are affected by BQ and tobacco components.