C
Chang-Shen Lin
Researcher at Kaohsiung Medical University
Publications - 68
Citations - 6760
Chang-Shen Lin is an academic researcher from Kaohsiung Medical University. The author has contributed to research in topics: Cancer & Carcinogenesis. The author has an hindex of 22, co-authored 60 publications receiving 6079 citations. Previous affiliations of Chang-Shen Lin include Tri-Service General Hospital & National Sun Yat-sen University.
Papers
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Journal ArticleDOI
Targeting DNA Damage Response and Immune Checkpoint for Anticancer Therapy
TL;DR: The mechanisms of DDR and their crucial roles in cancer therapy based on the concepts of synthetic lethality and ICB are discussed and the contemporary clinical trials of DDR-targeting and ICb therapies in breast, colorectal, and pancreatic cancers are included.
Journal ArticleDOI
Cancer cell reprogramming to identify the genes competent for generating liver cancer stem cells.
Kenly Wuputra,Chang-Shen Lin,Chang-Shen Lin,Ming-Ho Tsai,Chia-Chen Ku,Wen-Hsin Lin,Ya-Han Yang,Kung-Kai Kuo,Kazunari K. Yokoyama +8 more
TL;DR: The present review summarizes the current understanding of transcription factors involved in the generation of liver CSCs from liver cancer cell-derived iPSCs and how these contribute to oncogenesis, and discusses the modeling of liver cancer development.
Journal ArticleDOI
Generation of Human Stomach Cancer iPSC-Derived Organoids Induced by Helicobacter pylori Infection and Their Application to Gastric Cancer Research
Chia-Chen Ku,Kenly Wuputra,Jia-Bin Pan,Chia-Pei Li,Chung Jung Liu,Yi-Chang Liu,Shigeo Saito,Techuan Chan,Chang-Shen Lin,Deng-Chyang Wu,Kazunari K. Yokoyama +10 more
TL;DR: The conditions required for stomach-cancer-derived organoids induced by Helicobacter pylori in vitro and the ability of such models for testing the use of anticancer agents are examined.
Book ChapterDOI
Application of Host Cell Reactivation in Evaluating the Effects of Anticancer Drugs and Environmental Toxicants on Cellular DNA Repair Activity in Head and Neck Cancer
TL;DR: The application of an easy, fast and measurable in vivo functional assay for nucleotide excision repair (NER) and DNA repair via homologous recombination and non-homologous end-joining (NHEJ) pathways is shown to examine the cellular DNA repair activity responding to anticancer drugs or environmental toxicants.
Journal ArticleDOI
Expression of FOXM1 and Aurora-A predicts prognosis and sorafenib efficacy in patients with hepatocellular carcinoma.
Wen-Lung Su,Shih-Chang Chuang,Yu-Chu Wang,Lin-An Chen,Jian-Wei Huang,Wen-Tsan Chang,Shen-Nien Wang,King-Teh Lee,Chang-Shen Lin,Kung-Kai Kuo +9 more
TL;DR: The co-expression of FOXM1 and Aurora-A could be a reliable biomarker to predict the sorafenib response and prognosis of HCC patients.