C
Chang-Ting Chen
Researcher at University of California, Los Angeles
Publications - 5
Citations - 338
Chang-Ting Chen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Auxotrophy & Methanol. The author has an hindex of 4, co-authored 5 publications receiving 265 citations.
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Journal ArticleDOI
Building carbon–carbon bonds using a biocatalytic methanol condensation cycle
Igor W. Bogorad,Chang-Ting Chen,Matthew K. Theisen,Tung-Yun Wu,Alicia R. Schlenz,Albert T. Lam,James C. Liao +6 more
TL;DR: A biocatalytic pathway is demonstrated by combining the nonoxidative glycolysis with the ribulose monophosphate pathway to convert methanol to higher-chain alcohols or other acetyl-CoA derivatives using enzymatic reactions in a carbon-conserved and ATP-independent system.
Journal ArticleDOI
Frontiers in microbial 1-butanol and isobutanol production
Chang-Ting Chen,James C. Liao +1 more
TL;DR: Progress in metabolic engineering for the production of 1-Butanol and isobutanol using various resources is reviewed, which provides opportunities to access a wide spectrum of renewable resources.
Journal ArticleDOI
Synthetic methanol auxotrophy of Escherichia coli for methanol-dependent growth and production.
Chang-Ting Chen,Frederic Y.-H. Chen,Frederic Y.-H. Chen,Igor W. Bogorad,Tung-Yun Wu,Ruoxi Zhang,Abraxa S. Lee,James C. Liao +7 more
TL;DR: Genome sequencing and reversion of mutations indicated that mutations on genes encoding for adenylate cyclase and the formaldehyde detoxification operon were necessary for the growth phenotype, creating a phenotype termed "synthetic methanol auxotrophic".
Journal ArticleDOI
Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1.
Tung-Yun Wu,Chang-Ting Chen,Jessica Tse-Jin Liu,Igor W. Bogorad,Robert Damoiseaux,James C. Liao +5 more
TL;DR: This work characterized and engineered a group III NAD-dependent alcohol dehydrogenase (Mdh2) from Cupriavidus necator N-1, the first NAD- dependent Mdh characterized from a Gram-negative, mesophilic, non-methylotrophic organism with a significant activity towards methanol.
Journal ArticleDOI
Corrigendum to "Synthetic methanol auxotrophy of Escherichia coli for methanol-dependent growth and production" [Metab. Eng. 49 (2018) 257-266].
Chang-Ting Chen,Frederic Y.-H. Chen,Igor W. Bogorad,Tung-Yun Wu,Jason Derks,Ruoxi Zhang,Abraxa S. Lee,Matthew E. Jones,James C. Liao +8 more