R
Robert Damoiseaux
Researcher at University of California, Los Angeles
Publications - 189
Citations - 9100
Robert Damoiseaux is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Gene & Cancer. The author has an hindex of 44, co-authored 169 publications receiving 7227 citations. Previous affiliations of Robert Damoiseaux include University of Lausanne & University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.
Angel Garcia-Diaz,Daniel Sanghoon Shin,Blanca Homet Moreno,Justin Saco,Helena Escuin-Ordinas,Gabriel Abril Rodriguez,Jesse M. Zaretsky,Lu Sun,Willy Hugo,Xiaoyan Wang,Giulia Parisi,Cristina Puig Saus,Davis Y. Torrejon,Thomas G. Graeber,Begonya Comin-Anduix,Siwen Hu-Lieskovan,Robert Damoiseaux,Roger S. Lo,Antoni Ribas +18 more
TL;DR: Analysis of biopsy specimens from patients with melanoma confirmed interferon signature enrichment and upregulation of gene targets for STAT1/STAT2/STAT3 and IRF1 in anti-PD-1-responding tumors.
Journal ArticleDOI
Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation
Haiyuan Zhang,Zhaoxia Ji,Tian Xia,Huan Meng,Cecile Low-Kam,Rong Liu,Suman Pokhrel,Sijie Lin,Xiang Wang,Yu-Pei Liao,Meiying Wang,Linjiang Li,Robert Rallo,Robert Damoiseaux,Donatello Telesca,Lutz Mädler,Yoram Cohen,Jeffrey I. Zink,Andre E. Nel +18 more
TL;DR: It is demonstrated that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premisedon oxidative stress.
Journal ArticleDOI
Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping
Saji George,Suman Pokhrel,Tian Xia,Benjamin Gilbert,Zhaoxia Ji,Marco Schowalter,Andreas Rosenauer,Robert Damoiseaux,Kenneth A. Bradley,Lutz Mädler,Andre E. Nel +10 more
TL;DR: The utility of a rapid throughput, integrated biological oxidative stress response pathway to perform hazard ranking of a small batch of metal oxide nanoparticles is demonstrated, in addition to showing how this assay can be used to improve nanosafety by decreasing ZnO dissolution through Fe doping.
Journal ArticleDOI
Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.
Saji George,Tian Xia,Robert Rallo,Robert Rallo,Yan Zhao,Zhaoxia Ji,Sijie Lin,Xiang Wang,Haiyuan Zhang,David Schoenfeld,Robert Damoiseaux,Rong Liu,Shuo Lin,Kenneth A. Bradley,Yoram Cohen,Andre E. Nel +15 more
TL;DR: A multiparametric, automated screening assay that incorporates sublethal and lethal cellular injury responses to perform high-throughput analysis of a batch of commercial metal/metal oxide nanoparticles (NP) with the inclusion of a quantum dot (QD1) is reported.
Journal ArticleDOI
Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection
Momoko Watanabe,Jessie E. Buth,Neda Vishlaghi,Luis de la Torre-Ubieta,Jiannis Taxidis,Baljit S. Khakh,Giovanni Coppola,Caroline A. Pearson,Ken Yamauchi,Danyang Gong,Xinghong Dai,Robert Damoiseaux,Roghiyh Aliyari,Simone Liebscher,Katja Schenke-Layland,Katja Schenke-Layland,Katja Schenke-Layland,Christine Caneda,Christine Caneda,Eric J. Huang,Ye Zhang,Ye Zhang,Genhong Cheng,Daniel H. Geschwind,Peyman Golshani,Ren Sun,Bennett G. Novitch +26 more
TL;DR: Optimized organoid culture methods are described that efficiently and reliably produce cortical and basal ganglia structures similar to those in the human fetal brain in vivo and are demonstrated for modeling the teratogenic effects of Zika virus on the developing brain and identifying more susceptibility receptors and therapeutic compounds that can mitigate its destructive actions.