C
Changshun Shao
Researcher at Soochow University (Suzhou)
Publications - 169
Citations - 9677
Changshun Shao is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Mesenchymal stem cell & Mitotic crossover. The author has an hindex of 44, co-authored 152 publications receiving 7338 citations. Previous affiliations of Changshun Shao include University of Cincinnati Academic Health Center & Indiana University.
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Journal ArticleDOI
COVID-19 infection: the perspectives on immune responses.
Yufang Shi,Ying Wang,Changshun Shao,Jianan Huang,Jianhe Gan,Xiaoping Huang,Enrico M. Bucci,Mauro Piacentini,Giuseppe Ippolito,Gerry Melino +9 more
TL;DR: The role of asymptomatic SARS-CoV-2 infected individuals in disseminating the infection remains to be defined and the conventional wisdom based on overall immunity of the infected patients cannot explain this broad spectrum in disease presentation.
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Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
TL;DR: Current understanding of the immunomodulatory mechanisms of MSCs and issues related to their therapeutic application are discussed, which suggest the plasticity of immunoregulation by M SCs is controlled by the intensity and complexity of inflammatory stimuli.
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Inflammatory Cytokine-Induced Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1 in Mesenchymal Stem Cells Are Critical for Immunosuppression
Guangwen Ren,Xin Zhao,Liying Zhang,Jimin Zhang,Andrew L'Huillier,Weifang Ling,Arthur I. Roberts,Anh D. Le,Songtao Shi,Changshun Shao,Yufang Shi,Yufang Shi +11 more
TL;DR: A novel function of adhesion molecules in immunoregulation by MSCs is revealed and new insights for the clinical studies of antiadhesion therapies in various immune disorders are provided.
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Embryonic stem cells and somatic cells differ in mutation frequency and type
TL;DR: It is shown that mutation in murine ES cells, heterozygous at the selectable Aprt locus, differs from that in embryonic somatic cells, and the increased risk of tumor formation after stem cell therapy should be viewed with concern.
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Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1.
Yashu Zhu,Zhao Sun,Qin Han,Lianming Liao,Jianwei Wang,Chunjing Bian,Jie Li,Xi Yan,Yanning Liu,Changshun Shao,Robert Chunhua Zhao +10 more
TL;DR: DKK-1 (dickkopf-1), secreted by MSCs and acting as a negative regulator of WNT signaling pathway, is identified to be one of the molecules responsible for the inhibitory effect on tumor proliferation.