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Robert Chunhua Zhao
Researcher at Peking Union Medical College
Publications - 232
Citations - 16071
Robert Chunhua Zhao is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 59, co-authored 200 publications receiving 13605 citations. Previous affiliations of Robert Chunhua Zhao include University of Medicine and Dentistry of New Jersey & Peking Union Medical College Hospital.
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Journal ArticleDOI
Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide.
Guangwen Ren,Liying Zhang,Xin Zhao,Guangwu Xu,Yingyu Zhang,Arthur I. Roberts,Robert Chunhua Zhao,Yufang Shi +7 more
TL;DR: It is found that proinflammatory cytokines are required to induce immunosuppression by MSCs through the concerted action of chemokines and NO.
Journal ArticleDOI
Transplantation of ACE2 - Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia.
Zikuan Leng,Rongjia Zhu,Wei Hou,Yingmei Feng,Yanlei Yang,Qin Han,Guangliang Shan,Fanyan Meng,Dongshu Du,Shihua Wang,Junfen Fan,Wenjing Wang,Luchan Deng,Hongbo Shi,Hongjun Li,Zhongjie Hu,Fengchun Zhang,Jinming Gao,Hongjian Liu,Xiaoxia Li,Yangyang Zhao,Kan Yin,Xijing He,Zhengchao Gao,Yibin Wang,Bo Yang,Ronghua Jin,Ilia Stambler,Lee Wei Lim,Huanxing Su,Alexey Moskalev,Antonio Cano,Sasanka Chakrabarti,Kyung-Jin Min,Georgina M. Ellison-Hughes,Calogero Caruso,Kunlin Jin,Robert Chunhua Zhao +37 more
TL;DR: The intravenous transplantation of MSCs was safe and effective for treatment in patients with COVID-19 pneumonia, especially for the patients in critically severe condition.
Journal ArticleDOI
Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo.
TL;DR: Because ADAS cells can be expanded in culture without obvious senescence for more than 20 population doublings, they may be a potential source of endothelial cells for cellular pro-angiogenic therapies.
Journal ArticleDOI
Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells.
Wei Zhang,Wei Ge,Chang-hong Li,Shengguo You,Lianming Liao,Qin Han,Weimin Deng,Robert Chunhua Zhao +7 more
TL;DR: Both MSCs and their supernatants interfered with endocytosis of DCs, decreased their capacity to secret IL-12 and activate alloreactive T cells, and contribute to immunoregulation and development.
Journal ArticleDOI
Clinical applications of mesenchymal stem cells
TL;DR: An overview of the recent clinical findings related to MSC therapeutic effects is provided, including roles of MSCs in clinical trials conducted to treat graft-versus-host-disease (GVHD) and cardiovascular diseases are highlighted.