Chantal Fregimilicka

TL;DR: In COPD, the airway epithelium displays features of de-differentiation towards mesenchymal cells, which correlate with peribronchial fibrosis and airflow limitation, and which are partly due to a TGF-β1-driven epithelial reprogramming.

TL;DR: The COPD airway epithelium displays altered differentiation for ciliated cells, which recapitulates in vitro, at least in part through TGF-β1, which is hypothesized to cause bronchial epithelial cell lineage specification to be dysregulated.

TL;DR: This study shows that IgA production occurs in peribronchiolar LFs from severe COPD, where IL‐21‐producing T cells are present, and presumably represents a feature of exacerbated mucosal adaptive immune responses against microbial and/or self‐antigens.

TL;DR: In this paper, the authors explored mucosal IgA transport in lung cancer patients and found that Asthma is associated with increased lung IgE production, but whether the secretory IgA system is affected in this disease remains unknown.

TL;DR: Altered ciliogenesis correlate with disease severity and is recapitulated in vitro through an intrinsic reprogramming, at least partly mediated by TGF-1.