M
Maha Zohra Ladjemi
Researcher at University of Paris
Publications - 24
Citations - 626
Maha Zohra Ladjemi is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Respiratory epithelium. The author has an hindex of 10, co-authored 19 publications receiving 362 citations. Previous affiliations of Maha Zohra Ladjemi include Sorbonne & Université catholique de Louvain.
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Journal ArticleDOI
Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition.
Sophie Gohy,Cloé Hupin,Chantal Fregimilicka,Bruno Detry,Caroline Bouzin,Héloïse Gaide Chevronay,Marylène Lecocq,Birgit Weynand,Maha Zohra Ladjemi,Christophe E. Pierreux,Philippe Birembaut,Myriam Polette,Charles Pilette +12 more
TL;DR: In COPD, the airway epithelium displays features of de-differentiation towards mesenchymal cells, which correlate with peribronchial fibrosis and airflow limitation, and which are partly due to a TGF-β1-driven epithelial reprogramming.
Journal ArticleDOI
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity.
Melissa Saichi,Maha Zohra Ladjemi,Sarantis Korniotis,Christophe Rousseau,Zakaria Ait Hamou,Lucile Massenet-Regad,Lucile Massenet-Regad,Elise Amblard,Floriane Noël,Y. Marie,Y. Marie,Delphine Bouteiller,Jasna Medvedovic,Frédéric Pène,Vassili Soumelis +14 more
TL;DR: In this paper, the authors performed single-cell RNA-sequencing to establish a high-resolution map of blood antigen-presenting cells (APCs) in 15 patients with moderate or severe COVID-19 pneumonia, at day 1 and day 4 post admission to intensive care unit or pulmonology department.
Journal ArticleDOI
Chronic inflammatory airway diseases: the central role of the epithelium revisited
TL;DR: Better understanding of normal and altered epithelial functions continuously provides new insights into the physiopathology of chronic airway diseases and should help to identify new epithelial‐targeted therapies.
Posted ContentDOI
Single cell RNA sequencing of blood antigen-presenting cells in severe Covid-19 reveals multi-process defects in antiviral immunity
Melissa Saichi,Maha Zohra Ladjemi,Sarantis Korniotis,Christophe Rousseau,Zakaria Ait-Hamou,Lucile Massenet,Elise Amblard,Floriane Noel,Yannick Marie,Yannick Marie,Delphine Bouteiller,Jasna Medvedovic,Frédéric Pène,Vassili Soumelis +13 more
TL;DR: In this article, the authors performed single-cell RNA-sequencing to establish an exhaustive high-resolution map of blood antigen-presenting cells (APC) in 7 COVID-19 patients with moderate or severe pneumonia, at day-1 and day-4 post-admission, and two healthy donors.
Journal ArticleDOI
Altered generation of ciliated cells in chronic obstructive pulmonary disease.
Sophie Gohy,Sophie Gohy,François M. Carlier,Chantal Fregimilicka,Bruno Detry,Marylène Lecocq,Maha Zohra Ladjemi,Stijn E. Verleden,Delphine Hoton,Birgit Weynand,Caroline Bouzin,Charles Pilette,Charles Pilette +12 more
TL;DR: The COPD airway epithelium displays altered differentiation for ciliated cells, which recapitulates in vitro, at least in part through TGF-β1, which is hypothesized to cause bronchial epithelial cell lineage specification to be dysregulated.