Christophe E. Pierreux

TL;DR: It is suggested that biliary development proceeds according to a new mode of tubulogenesis characterized by transient asymmetry and whose timing is controlled by SOX9.

TL;DR: A gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages.

TL;DR: Using an inducible form of Raf in MDCK cells, it is shown that sustained activation of Raf alone is able to induce the transition from an epithelial to a mesenchymal phenotype, and the Raf-MAP kinase pathway thus synergizes with TGF beta in promoting malignancy but does not directly impair TGFbeta-induced Smad signaling.

TL;DR: It is demonstrated that inhibition of CRM1-mediated nuclear export by treatment of cells with leptomycin B results in endogenous Smad4 accumulating very rapidly in the nucleus, indicating that the nucleocytoplasmic shuttling is specific for Smad 4.

TL;DR: It is shown that, at E13-E18, the embryonic stage during which the major burst of beta-cell neogenesis takes place, pancreatic duct cells express Hnf1beta, the product of the maturity-onset diabetes of the young type 5 (MODY5) gene, which is defined as a precursor cellular stage of the embryonic pancreas and placed in a genetic hierarchy that regulates the generation of pancreatic endocrine cells.