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Chantelle F. Sephton
Researcher at Laval University
Publications - 31
Citations - 2155
Chantelle F. Sephton is an academic researcher from Laval University. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 13, co-authored 23 publications receiving 1845 citations. Previous affiliations of Chantelle F. Sephton include University of Texas Southwestern Medical Center & University of Saskatchewan.
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Journal ArticleDOI
Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes
Chantelle F. Sephton,Can Cenik,Alper Kucukural,Eric B. Dammer,Basar Cenik,YuHong Han,Colleen M. Dewey,Frederick P. Roth,Joachim Herz,Junmin Peng,Melissa J. Moore,Melissa J. Moore,Gang Yu +12 more
TL;DR: This work reveals the protein and RNA components of the TDP-43-containing ribonucleoprotein complexes and provides a framework for understanding how dysregulation of T DP-43 in RNA metabolism contributes to neurodegeneration.
Journal ArticleDOI
TDP-43 is a developmentally regulated protein essential for early embryonic development.
Chantelle F. Sephton,Shannon K. Good,Stan D. Atkin,Colleen M. Dewey,Paul R. Mayer,Joachim Herz,Gang Yu +6 more
TL;DR: It is shown that TDP-43 is a nuclear protein with persistent high-level expression during embryonic development and with progressively decreased protein levels during postnatal development, indicating that TDF is developmentally regulated and indispensible for early embryonic development.
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TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
Colleen M. Dewey,Basar Cenik,Basar Cenik,Chantelle F. Sephton,Daniel R. Dries,Paul Mayer,Shannon K. Good,Brett A. Johnson,Joachim Herz,Gang Yu +9 more
TL;DR: This study establishes sorbitol as a novel physiological stressor that directs TDP-43 to stress granules in Hek293T cells and primary cultured glia and proposes that mutant TDP -43 alters stress granule dynamics, which may contribute to the progression of T DP-43 proteinopathies.
Journal ArticleDOI
TDP-43 aggregation in neurodegeneration: are stress granules the key?
Colleen M. Dewey,Basar Cenik,Basar Cenik,Chantelle F. Sephton,Brett A. Johnson,Joachim Herz,Gang Yu +6 more
TL;DR: The "independent model" stipulates that TDP-43 aggregation is independent of stress granule formation, in contrast to the "precursor model" which presents the idea that stress granules formation contributes to a TDP"-43 aggregate "seed" and that chronic stress leads to concentration-dependent TDP -43 aggregation.
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Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration
TL;DR: Revealing the cell surface receptors and the intracellular functions of granulins and progranulin is crucial for understanding their contributions to neurodegeneration.