J
Joachim Herz
Researcher at University of Texas Southwestern Medical Center
Publications - 340
Citations - 48795
Joachim Herz is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: LDL receptor & Receptor. The author has an hindex of 107, co-authored 332 publications receiving 45606 citations. Previous affiliations of Joachim Herz include University of Texas Health Science Center at San Antonio & Max Planck Society.
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Journal ArticleDOI
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Hisayuki Shigematsu,Hisayuki Shigematsu,Li Lin,Takao Takahashi,Masaharu Nomura,Makoto Suzuki,Ignacio I. Wistuba,Kwun M. Fong,Huei Lee,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,Ziding Feng,Jack A. Roth,Joachim Herz,John D. Minna,Adi F. Gazdar +16 more
TL;DR: EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers, and can lead to lung cancer pathogenesis.
Journal ArticleDOI
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.
Shun Ishibashi,Michael S. Brown,Joseph L. Goldstein,Robert D. Gerard,Robert E. Hammer,Joachim Herz +5 more
TL;DR: It is concluded that the LDL receptor is responsible in part for the low levels of VLDL, IDL, and LDL in wild-type mice and that adenovirus-encoded LDL receptors can acutely reverse the hypercholesterolemic effects of LDL receptor deficiency.
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Suppression of Aging in Mice by the Hormone Klotho
Hiroshi Kurosu,Masaya Yamamoto,Jeremy D. Clark,Johanne Pastor,Animesh Nandi,Prem Gurnani,Owen P. McGuinness,Hirotaka Chikuda,Masayuki Yamaguchi,Hiroshi Kawaguchi,Iichiro Shimomura,Yoshiharu Takayama,Joachim Herz,C. Ronald Kahn,Kevin P. Rosenblatt,Makoto Kuro-o +15 more
TL;DR: It is shown that overexpression of Klotho in mice extends life span and it is suggested that Klotha-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties.
Journal ArticleDOI
Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Marion Trommsdorff,Michael Gotthardt,Thomas Hiesberger,John M. Shelton,Walter Stockinger,Johannes Nimpf,Robert E. Hammer,James A. Richardson,Joachim Herz +8 more
TL;DR: It is suggested that VLDLR and ApoER2 participate in transmitting the extracellular Reelin signal to intracellular signaling processes initiated by mDab1, a cytosolic protein that activates tyrosine kinases.