C
Char-Chang Shieh
Researcher at University of Mississippi Medical Center
Publications - 29
Citations - 1866
Char-Chang Shieh is an academic researcher from University of Mississippi Medical Center. The author has contributed to research in topics: Potassium channel & Patch clamp. The author has an hindex of 19, co-authored 29 publications receiving 1805 citations.
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Journal Article
Potassium Channels: Molecular Defects, Diseases, and Therapeutic Opportunities
TL;DR: This review aims to provide an understanding of K(+) channel function at the molecular level in the context of disease processes and discuss the progress, hurdles, challenges, and opportunities in the exploitation of K(* channels as therapeutic targets by pharmacological and emerging genetic approaches.
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P2X7-related modulation of pathological nociception in rats
Steve McGaraughty,K.L. Chu,Marian T. Namovic,Diana L. Donnelly-Roberts,R.R. Harris,X.-F. Zhang,Char-Chang Shieh,Carol T. Wismer,C.Z. Zhu,Donna M. Gauvin,A.C. Fabiyi,Prisca Honore,Robert J. Gregg,Michael E. Kort,D.W. Nelson,William A. Carroll,Kennan C. Marsh,Connie R. Faltynek,Michael F. Jarvis +18 more
TL;DR: ATP, acting through the P2X7 receptor, exerts a wide-ranging influence on spinal neuronal activity following a chronic injury and is likely mediated through immuno-neural interactions that affect the release of endogenous cytokines.
Journal ArticleDOI
Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states.
S.K. Joshi,Joseph P. Mikusa,Gricelda Hernandez,Scott J. Baker,Char-Chang Shieh,Torben R. Neelands,Xu-Feng Zhang,Wende Niforatos,Karen Kage,Ping Han,Douglas S. Krafte,Connie R. Faltynek,James P. Sullivan,Michael F. Jarvis,Prisca Honore +14 more
TL;DR: A greater involvement of Nav 1.8 in frank nerve injury and inflammatory pain as compared to acute, post‐operative or chemotherapy‐induced neuropathic pain states is demonstrated.
Journal ArticleDOI
Painful purinergic receptors.
Diana L. Donnelly-Roberts,Steve McGaraughty,Char-Chang Shieh,Prisca Honore,Michael F. Jarvis +4 more
TL;DR: Some of the recent advances to identify selective P2 receptor ligands, which has enhanced the investigation of ATP-related modulation of pain sensitivity, are highlighted.
Journal ArticleDOI
Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation
TL;DR: Results demonstrate that IK(Ca) channels play an important role in the regulation of human prostate cancer cell proliferation.