M
Marian T. Namovic
Researcher at Rosalind Franklin University of Medicine and Science
Publications - 37
Citations - 2020
Marian T. Namovic is an academic researcher from Rosalind Franklin University of Medicine and Science. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 19, co-authored 36 publications receiving 1884 citations.
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Journal ArticleDOI
A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat
Prisca Honore,Diana L. Donnelly-Roberts,Marian T. Namovic,Gin C. Hsieh,Chang Z. Zhu,Joe Mikusa,Gricelda Hernandez,Chengmin Zhong,Donna M. Gauvin,Prasant Chandran,Richard R. Harris,Arturo Perez Medrano,William A. Carroll,Kennan C. Marsh,James P. Sullivan,Connie R. Faltynek,Michael F. Jarvis +16 more
TL;DR: It is demonstrated that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain.
Journal ArticleDOI
Structure−Activity Relationship Studies on a Series of Novel, Substituted 1-Benzyl-5-phenyltetrazole P2X7 Antagonists
Derek W. Nelson,Robert J. Gregg,Michael E. Kort,Arturo Perez-Medrano,Voight Eric,Ying Wang,George K. Grayson,Marian T. Namovic,Diana L. Donnelly-Roberts,Wende Niforatos,Prisca Honore,Michael F. Jarvis,Connie R. Faltynek,William A. Carroll +13 more
TL;DR: 1-Benzyl-5-aryltetrazoles were discovered to be novel antagonists for the P2X(7) receptor and advanced to efficacy studies in a model of neuropathic pain where significant reversal of mechanical allodynia was observed at doses that did not affect motor coordination.
Journal ArticleDOI
P2X7-related modulation of pathological nociception in rats
Steve McGaraughty,K.L. Chu,Marian T. Namovic,Diana L. Donnelly-Roberts,R.R. Harris,X.-F. Zhang,Char-Chang Shieh,Carol T. Wismer,C.Z. Zhu,Donna M. Gauvin,A.C. Fabiyi,Prisca Honore,Robert J. Gregg,Michael E. Kort,D.W. Nelson,William A. Carroll,Kennan C. Marsh,Connie R. Faltynek,Michael F. Jarvis +18 more
TL;DR: ATP, acting through the P2X7 receptor, exerts a wide-ranging influence on spinal neuronal activity following a chronic injury and is likely mediated through immuno-neural interactions that affect the release of endogenous cytokines.
Journal ArticleDOI
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors
TL;DR: Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel and sustained P2x7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface.
Journal ArticleDOI
Mitogen-Activated Protein Kinase and Caspase Signaling Pathways Are Required for P2X7 Receptor (P2X7R)-Induced Pore Formation in Human THP-1 Cells
TL;DR: The hypothesis that downstream cellular signaling mechanisms, rather than channel dilation, mediate cytolytic pore formation after prolonged agonist activation is supported, which underlies P2X7 receptors.