C
Charles A. Alt
Researcher at Eli Lilly and Company
Publications - 27
Citations - 739
Charles A. Alt is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Alkylation & Catalysis. The author has an hindex of 10, co-authored 27 publications receiving 718 citations.
Papers
More filters
Journal ArticleDOI
Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.
James A. Monn,Matthew John Valli,Steven March Massey,Rebecca A. Wright,Craig R. Salhoff,Bryan G. Johnson,Trevor J. Howe,Charles A. Alt,Rhodes Gary Anthony,Roger L. Robey,Kelly R. Griffey,Joseph P. Tizzano,Mary Jeanne Kallman,David R. Helton,Darryle D. Schoepp +14 more
TL;DR: In this paper, the authors showed that 9 would closely approximate the bioactive conformation of glutamate when acting at group 2 metabotropic glutamate receptors (mGluRs) in the rat cerebral cortical slice.
Journal ArticleDOI
Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties.
James A. Monn,Matthew John Valli,Steven March Massey,Rebecca A. Wright,Craig R. Salhoff,Bryan G. Johnson,Trevor J. Howe,Charles A. Alt,Rhodes Gary Anthony,Roger L. Robey,Kelly R. Griffey,Joseph P. Tizzano,Mary Jeanne Kallman,David R. Helton,Darryle D. Schoepp +14 more
TL;DR: In this article, the authors showed that 9 would closely approximate the bioactive conformation of glutamate when acting at group 2 metabotropic glutamate receptors (mGluRs) in the rat cerebral cortical slice.
Journal ArticleDOI
Synthesis of PPAR agonist via asymmetric hydrogenation of a cinnamic acid derivative and stereospecific displacement of (S)-2-chloropropionic acid.
Ioannis N. Houpis,Lawrence E. Patterson,Charles A. Alt,John R. Rizzo,Tony Y. Zhang,Michael Haurez +5 more
TL;DR: The synthesis of the peroxime proliferator activated receptor (PPAR) alpha,gamma-agonist was accomplished with high enantio- and diastereoselectivity by employing an asymmetric hydrogenation strategy, of an alpha-alkoxy cinnamic acid derivative, to set the C-2 chiral center.
Journal ArticleDOI
2-Alkoxydihydrocinnamates as PPAR agonists. Activity modulation by the incorporation of phenoxy substituents.
Jose Alfredo Martin,Dawn A. Brooks,Lourdes Prieto,Rosario Gonzalez,Alicia Torrado,Isabel Rojo,Beatrriz Lopez De Uralde,Carlos Lamas,Rafael Ferritto,Maria Dolores Martin-Ortega,Javier Agejas,Francisco Parra,John R. Rizzo,Rhodes Gary Anthony,Roger L. Robey,Charles A. Alt,Samuel R. Wendel,Tony Y. Zhang,Anne Reifel-Miller,Chahrzad Montrose-Rafizadeh,Joseph T. Brozinick,Eric D. Hawkins,Elizabeth A. Misener,Daniel A. Briere,Robert J. Ardecky,James D. Fraser,Warshawsky Alan M +26 more
TL;DR: A series of potent and selective PPARgamma agonists with moderate PPARalpha affinity and little to no affinity for other nuclear receptors are described, showing that these compounds are efficacious at low doses in glucose normalization and plasma triglyceride reduction.
Journal ArticleDOI
An expedient synthesis of 3-substituted indoles via reductive alkylation with ketones
TL;DR: In this article, 3-Alkylindoles were prepared from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid.