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Charles C. Maponga
Researcher at College of Health Sciences, Bahrain
Publications - 47
Citations - 597
Charles C. Maponga is an academic researcher from College of Health Sciences, Bahrain. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 12, co-authored 35 publications receiving 473 citations. Previous affiliations of Charles C. Maponga include University of Zimbabwe & University at Buffalo.
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Journal ArticleDOI
Multimodal nanoparticles that provide immunomodulation and intracellular drug delivery for infectious diseases.
Admire Dube,Jessica L. Reynolds,Wing Cheung Law,Charles C. Maponga,Paras N. Prasad,Paras N. Prasad,Gene D. Morse +6 more
TL;DR: A new nanoparticle design is proposed to address hard to treat infectious diseases such as TB, through the use of nanoparticles functionalized with ligands that are able to concurrently modulate the cellular immune response and deliver a drug.
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Safety and trough concentrations of nevirapine prophylaxis given daily, twice weekly, or weekly in breast-feeding infants from birth to 6 months.
Avinash K. Shetty,Hoosen M. Coovadia,Mark Mirochnick,Yvonne Maldonado,Lynne M. Mofenson,Susan H. Eshleman,Thomas Fleming,Thomas Fleming,Lynda Emel,Kathy George,David Katzenstein,Jennifer Wells,Charles C. Maponga,Anthony Mwatha,Samuel Adeniyi Jones,Salim S. Abdool Karim,Mary T. Bassett +16 more
TL;DR: The data indicate that NVP prophylaxis for 6 months was safe and well tolerated in infants and a phase 3 study is planned to assess the efficacy of OD infant NVP regimen to prevent breast-feeding HIV-1 transmission.
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Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.
TL;DR: Significant CYP3A4 inhibitory effects were found, with IC50 values of 0.5 and 2.5 mg/ml for leaf-methanol and leaf-water extracts, respectively, while root extracts were less active.
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Prevalence and patterns of Moringa oleifera use among HIV positive patients in Zimbabwe: a cross-sectional survey.
TL;DR: M. oleifera supplementation is common among HIV positive people and poses a potential risk for herb-drug interactions, so further experimental investigations into its effect on drug metabolism and transport would be useful in improving clinical outcome of HIV positive patients.
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The impact of herbal remedies on adverse effects and quality of life in HIV-infected individuals on antiretroviral therapy.
Nyashadzashe Bepe,Nathan Madanhi,Tinashe Mudzviti,Samuel Gavi,Charles C. Maponga,Gene D. Morse +5 more
TL;DR: There is evidence to suggest that some traditional herbal remedies used in Zimbabwe may increase incidence of certain types of adverse events when used in combination with antiretroviral drugs.