C
Charles H. Fraga
Researcher at University of Washington
Publications - 13
Citations - 472
Charles H. Fraga is an academic researcher from University of Washington. The author has contributed to research in topics: Vascular permeability & Bronchoalveolar lavage. The author has an hindex of 9, co-authored 13 publications receiving 450 citations. Previous affiliations of Charles H. Fraga include Boston Children's Hospital.
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Journal ArticleDOI
The role of proinflammatory cytokines in lung ischemia-reperfusion injury.
Baiya Krishnadasan,Babu V. Naidu,Karen Byrne,Charles H. Fraga,Edward D. Verrier,Michael S. Mulligan +5 more
TL;DR: Tumor necrosis factor alpha and interleukin 1beta help regulate the development of lung ischemia-reperfusion injury and appear to promote injury by altering expression of proinflammatory and anti-inflammatory cytokines and influencing tissue neutrophil recruitment.
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Simvastatin ameliorates injury in an experimental model of lung ischemia-reperfusion.
Babu V. Naidu,Steven M. Woolley,Alexander S. Farivar,Robert Thomas,Charles H. Fraga,Michael S. Mulligan +5 more
TL;DR: The potential to pretreat recipients of lung transplantation with statins to ameliorate reperfusion injury is promising and the protective effects of simvastatin are likely mediated by modulation of endothelial nitric oxide synthase.
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Critical role of reactive nitrogen species in lung ischemia–reperfusion injury
Babu V. Naidu,Charles H. Fraga,Andrew L. Salzman,Csaba Szabó,Edward D. Verrier,Michael S. Mulligan +5 more
TL;DR: The deleterious effects of lung ischemia-reperfusion injury are in part mediated by the formation of peroxynitrite, as enhanced decomposition of this species is protective in this model.
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Angiogenic proteins in the lungs of children after cavopulmonary anastomosis.
Sandra L. Starnes,Brian W. Duncan,James M. Kneebone,Geoffrey L. Rosenthal,Kathleen Patterson,Charles H. Fraga,Karen Kilian,Sanjeev K. Mathur,Flavian M. Lupinetti +8 more
TL;DR: The results suggest that vascular endothelial growth factor may be a mediator of angiogenesis in the lungs of children after cavopulmonary anastomosis; however, other factors, such as vascular dilation and remodeling, may also be important.
Journal ArticleDOI
Pulmonary microvessel density is a marker of angiogenesis in children after cavopulmonary anastomosis.
Sandra L. Starnes,Brian W. Duncan,James M. Kneebone,Charles H. Fraga,Shawn States,Geoffrey L. Rosenthal,Flavian M. Lupinetti +6 more
TL;DR: After cavopulmonary anastomosis, pulmonary microvessel density is increased even in the absence of clinically apparent pulmonary arteriovenous malformations, supporting the presence of a constant angiogenic stimulus.