Baiya Krishnadasan

TL;DR: Tumor necrosis factor alpha and interleukin 1beta help regulate the development of lung ischemia-reperfusion injury and appear to promote injury by altering expression of proinflammatory and anti-inflammatory cytokines and influencing tissue neutrophil recruitment.

TL;DR: It is likely that the alveolar macrophage is the key early source of multiple proinflammatory mediators that orchestrate lung ischemia-reperfusion injury and is protective against injury, supporting its central role in oxidant stress-induced cytokine and chemokine release and the subsequent development of lung injury.

TL;DR: Cyclosporine and tacrolimus treatment before reperfusion was protective against lung ischemia-reperfusion injury in rats, and the decreased expression of cytokine messenger RNA indicates that both cyclosporines and tacrosporine may exert their protective effects at the pretranscriptional level.

TL;DR: The findings suggest the potential mechanism of action of CSA's protective effects in lung ischemia reperfusion injury and attenuates the chemokine response of AMs in vitro to hypoxia and reoxygenation at the pretranscriptional level through modulation of NF-kappaB.

TL;DR: Resection for lung gangrene is possible even in the setting of diffuse parenchymal changes and ventilator dependency and a computed tomography scan of the chest is important to make the diagnosis of lung gangreen and to plan operative management.