C
Charles H. Vite
Researcher at University of Pennsylvania
Publications - 118
Citations - 5396
Charles H. Vite is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Leukodystrophy & Krabbe disease. The author has an hindex of 38, co-authored 115 publications receiving 4657 citations. Previous affiliations of Charles H. Vite include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease.
Allison M. Bradbury,David A. Peterson,Charles H. Vite,Steven Chen,N. Matthew Ellinwood,James M. Provenzale +5 more
TL;DR: Large decreases in FA values, increases in ADC values, and increases in RD (consistent with demyelination) values, were seen in white matter of the Krabbe brain but not gray matter.
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Central nervous system dysfunction associated with Rocky Mountain spotted fever infection in five dogs.
TL;DR: Although a higher mortality rate has been reported for dogs with neurological symptoms and RMSF infection, all of the dogs in this study improved with appropriate medical therapy and supportive care.
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Efficacy and Safety of a Krabbe Disease Gene Therapy
Juliette Hordeaux,Brianne A. Jeffrey,Jinlong Jian,Gourav Roy Choudhury,Kristofer Michalson,Thomas W. Mitchell,Elizabeth L. Buza,Jessica A. Chichester,Cecilia Dyer,Jessica H. Bagel,Charles H. Vite,Allison M. Bradbury,James F. Wilson +12 more
TL;DR: The studies demonstrate the efficacy, scalability, and safety of a single cisterna magna AAVhu68 administration to treat Krabbe disease and in nonhuman primates.
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In utero transplantation of monocytic cells in cats with α-mannosidosis
Janis L. Abkowitz,Kathleen M. Sabo,Zhantao Yang,Charles H. Vite,Laurence E. Shields,Mark E. Haskins +5 more
TL;DR: It is shown that the donor monocytic cells engraft and persist in the brain, liver, and spleen, albeit at levels below those needed to alter the clinical or pathological progression of the &agr;-mannosidosis, in the first study of monocyte transplantation in a large animal model of a lysosomal storage disorder.
Journal ArticleDOI
Infection and establishment of latency in the dog brain after direct inoculation of a nonpathogenic strain of herpes simplex virus-1.
Sandra L Springer,Charles H. Vite,Ara C Polesky,Santosh Kesari,Nigel W. Fraser,Nigel W. Fraser,John H. Wolfe,John H. Wolfe +7 more
TL;DR: When the nonpathogenic 1716 strain of HSV-1 was injected into the brains of normal dogs it established a latent infection without signs of pathology, and appears to be suitable as a vector for therapeutic, or marker genes, in this species.