C
Charles H. Vite
Researcher at University of Pennsylvania
Publications - 118
Citations - 5396
Charles H. Vite is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Leukodystrophy & Krabbe disease. The author has an hindex of 38, co-authored 115 publications receiving 4657 citations. Previous affiliations of Charles H. Vite include Hospital of the University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Aging in the Canine and Feline Brain
Charles H. Vite,Elizabeth Head +1 more
TL;DR: Neurodegenerative diseases such as lysosomal storage diseases in dogs and cats also show similar features of human aging, suggesting some common underlying pathogenic mechanisms and also suggesting pathways that can be modified to promote healthy brain aging.
Journal ArticleDOI
Globoid cell leukodystrophy in Cairn and West Highland white terriers
David A. Wenger,Teresa Victoria,Mohammad A. Rafi,Paola Luzi,Marie T. Vanier,Charles H. Vite,D F Patterson,M H Haskins +7 more
TL;DR: Through a screening test based on the molecular defect found in these breeds, over 50 cairn terrier carriers have been identified and a colony of five carrier dogs has been established and successful treatment of this canine model will lead to studies in some humans with GLD.
Journal ArticleDOI
Mining continuous intracranial EEG in focal canine epilepsy: Relating interictal bursts to seizure onsets
Kathryn A. Davis,Hoameng Ung,Drausin Wulsin,Joost B. Wagenaar,Emily B. Fox,Ned Patterson,Charles H. Vite,Gregory A. Worrell,Brian Litt +8 more
TL;DR: A long‐term iEEG dataset from canines with naturally occurring epilepsy is leveraged to investigate interictal bursts and their electrographic relationship to seizures.
Journal ArticleDOI
AAVrh10 Gene Therapy Ameliorates Central and Peripheral Nervous System Disease in Canine Globoid Cell Leukodystrophy (Krabbe Disease)
Allison M. Bradbury,Mohammed A Rafi,Jessica H. Bagel,Becky K. Brisson,Michael S. Marshall,Jill Pesayco Salvador,Xuntain Jiang,Gary P. Swain,Maria Prociuk,Patricia O'Donnell,Caitlin A. Fitzgerald,Daniel S. Ory,Ernesto R. Bongarzone,Ernesto R. Bongarzone,G. Diane Shelton,David A. Wenger,Charles H. Vite +16 more
TL;DR: For the first time, therapeutic effect has been established in the canine model of GLD by targeting both peripheral and central nervous system impairments with potential clinical implications for GLD patients.
Journal ArticleDOI
Histopathology, electrodiagnostic testing, and magnetic resonance imaging show significant peripheral and central nervous system myelin abnormalities in the cat model of alpha-mannosidosis.
Charles H. Vite,Joseph C. McGowan,Kyle G. Braund,Kenneth J. Drobatz,Jerry D. Glickson,John H. Wolfe,Mark E. Haskins +6 more
TL;DR: In this article, the authors characterized the peripheral nervous system and central nervous system myelin abnormalities in cats from a breeding colony with a uniform mutation in the gene encoding alpha-mannosidase.