C
Charles H. Vite
Researcher at University of Pennsylvania
Publications - 118
Citations - 5396
Charles H. Vite is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Leukodystrophy & Krabbe disease. The author has an hindex of 38, co-authored 115 publications receiving 4657 citations. Previous affiliations of Charles H. Vite include Hospital of the University of Pennsylvania.
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Journal ArticleDOI
Results of cerebrospinal fluid analysis, neurologic examination findings, and age at the onset of seizures as predictors for results of magnetic resonance imaging of the brain in dogs examined because of seizures: 115 cases (1992-2000).
William W. Bush,Christina S Barr,Edwin W Darrin,Frances S. Shofer,Charles H. Vite,Sheldon A. Steinberg +5 more
TL;DR: Results suggest that neurologic examination findings and results of CSF analysis are useful in predicting whether results of MRI will be abnormal in dogs examined because of seizures, but age at the onset of seizures is not.
Journal ArticleDOI
Signs of neurologic dysfunction in dogs with central versus peripheral vestibular disease.
TL;DR: It is suggested that nonambulatory tetraparesis is significantly more common in dogs with CVD and veer or lean in 1 direction and to have resting nystagmus may be useful in distinguishing the 2 conditions.
Journal ArticleDOI
Mechanism of Neuromuscular Dysfunction in Krabbe Disease
Ludovico Cantuti-Castelvetri,Erick J. Maravilla,Michael S. Marshall,Tammy Tamayo,Ludovic D'Auria,John Monge,James Jeffries,Tuba Sural-Fehr,Aurora Lopez-Rosas,Guannan Li,Kelly D. Garcia,Richard B. van Breemen,Charles H. Vite,Jesús García,Ernesto R. Bongarzone +14 more
TL;DR: This work indicates that muscular dysfunction in Krabbe disease is compounded by a pathogenic mechanism involving at least the failure of NMJ function, activation of proteosome degradation, and a reduction of the Akt pathway.
Journal ArticleDOI
MRI and electrophysiological abnormalities in a case of canine globoid cell leucodystrophy
TL;DR: Electrodiagnostic testing revealed evidence of peripheral neuropathy and an abnormal brainstem auditory evoked response that may raise the suspicion of GCL in dogs and may aid in monitoring disease progression.
Journal ArticleDOI
Corrective GUSB transfer to the canine mucopolysaccharidosis VII brain.
Aurélie Cubizolle,Nicolas Serratrice,Nadia Skander,Marie-Anne Colle,Sandy Ibanes,Aurelie Gennetier,Neus Bayó-Puxan,Khalil Mazouni,Franck J. D. Mennechet,Béatrice Joussemet,Yan Cherel,Yaouen Lajat,Charles H. Vite,Florence Bernex,Vasiliki Kalatzis,Mark E. Haskins,Eric J. Kremer +16 more
TL;DR: The efficacy of a helper-dependent (HD) canine adenovirus (CAV-2) vector harboring a human GUSB expression cassette (HD-RIGIE) in the MPS VII dog brain was tested and demonstrated that it preferentially transduced neurons and axonal retrograde transport from the injection site to efferent regions was efficient.