C
Charles H. Vite
Researcher at University of Pennsylvania
Publications - 118
Citations - 5396
Charles H. Vite is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Leukodystrophy & Krabbe disease. The author has an hindex of 38, co-authored 115 publications receiving 4657 citations. Previous affiliations of Charles H. Vite include Hospital of the University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe's disease)
Allison M. Bradbury,Jessica H. Bagel,Xuntian Jiang,Gary P. Swain,Maria Prociuk,Caitlin A. Fitzgerald,Patricia O'Donnell,Kyle G. Braund,Daniel S. Ory,Charles H. Vite +9 more
TL;DR: Clinical relevant and quantifiable measures of central (CNS) and peripheral (PNS) nervous system disease progression in the naturally occurring canine model of GLD demonstrate that CNS and PNS disease progression can be quantified over time with tools identical to those used to assess human patients.
Journal ArticleDOI
Identification of the Rostral Migratory Stream in the Canine and Feline Brain
Saafan Z. Malik,Melissa J. Lewis,Alison Isaacs,Mark E. Haskins,Thomas J. Van Winkle,Charles H. Vite,Deborah Watson +6 more
TL;DR: In the adult rodent brain, neural progenitor cells migrate from the subventricular zone of the lateral ventricle towards the olfactory bulb in a track known as the rostral migratory stream (RMS).
Journal ArticleDOI
Detection of a genetic mutation for myotonia congenita among Miniature Schnauzers and identification of a common carrier ancestor
TL;DR: A PCR-based enzyme digestion DNA test was developed to detect the mutant skeletal muscle chloride channel (CIC-1) allele that causes myotonia congenita in Miniature Schnauzers and to analyze the relationship of affected and carrier dogs.
Journal ArticleDOI
Electrodiagnostic testing and histopathologic changes confirm peripheral nervous system myelin abnormalities in the feline model of niemann-pick disease type C.
Jessica H. Bagel,Tracey Sikora,Maria Prociuk,Jill P. Pesayco,Andrew P. Mizisin,G. Diane Shelton,Charles H. Vite +6 more
TL;DR: There was a shift to small myelinated fibers in affected cats, and there were significant decreases in fiber diameter, axon diameter, and myelin thickness, similar to those described in the murine NPC disease model and in rare patients in whom nerve biopsy has been performed.
Journal ArticleDOI
Clinical Improvement of Alpha-mannosidosis Cat Following a Single Cisterna Magna Infusion of AAV1.
Sea Young Yoon,Jessica H. Bagel,Patricia O'Donnell,Charles H. Vite,John H. Wolfe,John H. Wolfe +5 more
TL;DR: C cisterna magna gene delivery by AAV1 appears to be a viable strategy for treatment of the whole brain in AMD and should be applicable to many of the neurotropic LSDs as well as other neurogenetic disorders.