C
Charles L. Feldman
Researcher at Brigham and Women's Hospital
Publications - 10
Citations - 2277
Charles L. Feldman is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Coronary atherosclerosis & Artery. The author has an hindex of 9, co-authored 10 publications receiving 2068 citations. Previous affiliations of Charles L. Feldman include Harvard University & Northeastern University.
Papers
More filters
Journal ArticleDOI
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Yiannis S. Chatzizisis,Ahmet U. Coskun,Michael Jonas,Elazer R. Edelman,Elazer R. Edelman,Charles L. Feldman,Peter Stone +6 more
TL;DR: The molecular, cellular, and vascular processes supporting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling are explored and likely mechanisms concerning the different natural history trajectories of individual coronary lesions are indicated.
Journal ArticleDOI
Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study.
Peter Stone,Ahmet U. Coskun,Scott Kinlay,Maureen E. Clark,Milan Sonka,Andreas Wahle,Olusegun J. Ilegbusi,Yerem Yeghiazarians,Jeffrey J. Popma,John Orav,Richard E. Kuntz,Charles L. Feldman +11 more
TL;DR: This is the first experience in humans relating ESS to subsequent outcomes in native and stented arteries and shows regions of low ESS develop progressive atherosclerosis and outward remodeling, areas of physiological ESS remain quiescent, and areas of increased ESS exhibit outward remodelling.
Journal ArticleDOI
Determination of in vivo velocity and endothelial shear stress patterns with phasic flow in human coronary arteries: a methodology to predict progression of coronary atherosclerosis.
Charles L. Feldman,Olusegun J. Ilegbusi,Zhenjun Hu,Richard W. Nesto,Sergio Waxman,Peter Stone +5 more
TL;DR: A system that permits, for the first time, the in vivo determination of pulsatile local velocity patterns and endothelial shear stress in the human coronary arteries is described.
Journal ArticleDOI
Intravascular hemodynamic factors responsible for progression of coronary atherosclerosis and development of vulnerable plaque.
Charles L. Feldman,Peter Stone +1 more
TL;DR: The mechanisms that link hemodynamic factors to plaque development and rupture are outlined and some detail recently developed techniques that make it possible to determine these factors in vivo in patients during routine cardiac catheterization procedures are described.
Journal ArticleDOI
Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans.
Ahmet U. Coskun,Yerem Yeghiazarians,Scott Kinlay,Maureen E. Clark,Olusegun J. Ilegbusi,Andreas Wahle,Milan Sonka,Jeffrey J. Popma,Richard E. Kuntz,Charles L. Feldman,Peter Stone +10 more
TL;DR: The 3D anatomy and ESS of human coronary arteries can be reproducibly estimated in vivo and provides a tool to examine the effect of ESS on atherogenesis, remodeling, and restenosis; the contribution of arterial remodeling and plaque growth to changes in the lumen; and the impact of new therapies.