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Ahmet U. Coskun
Researcher at Northeastern University
Publications - 64
Citations - 4769
Ahmet U. Coskun is an academic researcher from Northeastern University. The author has contributed to research in topics: Coronary artery disease & Intravascular ultrasound. The author has an hindex of 22, co-authored 58 publications receiving 4267 citations. Previous affiliations of Ahmet U. Coskun include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
Yiannis S. Chatzizisis,Ahmet U. Coskun,Michael Jonas,Elazer R. Edelman,Elazer R. Edelman,Charles L. Feldman,Peter Stone +6 more
TL;DR: The molecular, cellular, and vascular processes supporting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling are explored and likely mechanisms concerning the different natural history trajectories of individual coronary lesions are indicated.
Journal ArticleDOI
Prediction of progression of coronary artery disease and clinical outcomes using vascular profiling of endothelial shear stress and arterial plaque characteristics: the PREDICTION Study.
Peter Stone,Shigeru Saito,Saeko Takahashi,Yasuhiro Makita,Shigeru Nakamura,Tomohiro Kawasaki,Akihiko Takahashi,Takaaki Katsuki,Sunao Nakamura,Atsuo Namiki,Atsushi Hirohata,Toshiyuki Matsumura,Seiji Yamazaki,Hiroyoshi Yokoi,Shinji Tanaka,Satoru Otsuji,Fuminobu Yoshimachi,Junko Honye,Dawn Harwood,Martha Reitman,Ahmet U. Coskun,Michail I. Papafaklis,Charles L. Feldman +22 more
TL;DR: In this article, a three-vessel vascular profiling (2.7 arteries per patient) was performed at baseline in 506 patients with acute coronary syndrome treated with a percutaneous coronary intervention and in a subset of 374 (74%) consecutive patients 6 to 10 months later to assess plaque natural history.
Journal ArticleDOI
Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study.
Peter Stone,Ahmet U. Coskun,Scott Kinlay,Maureen E. Clark,Milan Sonka,Andreas Wahle,Olusegun J. Ilegbusi,Yerem Yeghiazarians,Jeffrey J. Popma,John Orav,Richard E. Kuntz,Charles L. Feldman +11 more
TL;DR: This is the first experience in humans relating ESS to subsequent outcomes in native and stented arteries and shows regions of low ESS develop progressive atherosclerosis and outward remodeling, areas of physiological ESS remain quiescent, and areas of increased ESS exhibit outward remodelling.
Journal ArticleDOI
Shear-Activated Nanotherapeutics for Drug Targeting to Obstructed Blood Vessels
Netanel Korin,Mathumai Kanapathipillai,Benjamin D. Matthews,Marilena Crescente,Marilena Crescente,Alexander Brill,Alexander Brill,Tadanori Mammoto,Kaustabh Ghosh,Samuel Jurek,Sidi A. Bencherif,Sidi A. Bencherif,Deen Bhatta,Ahmet U. Coskun,Charles L. Feldman,Denisa D. Wagner,Denisa D. Wagner,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +19 more
TL;DR: A biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism—in the same way platelets do—to deliver drugs to obstructed blood vessels offers a potential new approach for treatment of life-threatening diseases that result from acute vascular occlusion.
Journal ArticleDOI
Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress An Intravascular Ultrasound and Histopathology Natural History Study
Yiannis S. Chatzizisis,Michael Jonas,Ahmet U. Coskun,Roy Beigel,Benjamin V. Stone,Charles Maynard,Ross G. Gerrity,William Lionel Daley,Campbell Rogers,Elazer R. Edelman,Elazer R. Edelman,Charles L. Feldman,Peter Stone,Peter Stone +13 more
TL;DR: Low ESS was an independent predictor of the development of high-risk plaques, characterized by intense lipid accumulation, inflammation, thin fibrous cap, severe internal elastic lamina degradation, and excessive expansive remodeling.