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Charles L. Goolsby
Researcher at Northwestern University
Publications - 76
Citations - 2676
Charles L. Goolsby is an academic researcher from Northwestern University. The author has contributed to research in topics: Immunophenotyping & Chronic lymphocytic leukemia. The author has an hindex of 30, co-authored 76 publications receiving 2591 citations. Previous affiliations of Charles L. Goolsby include University of Chicago & Rush University Medical Center.
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Journal ArticleDOI
Detection of HIV-1 DNA and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry
Bruce K. Patterson,Michele Till,Patricia Otto,Charles L. Goolsby,Manohar R. Furtado,Lincoln J. Mcbride,Steven M. Wolinsky +6 more
TL;DR: It is now possible to detect single-copy DNA or low-abundance messenger RNA rapidly and reproducibly in a minor subpopulation of cells in suspension at single-cell resolution and to sort those cells for further characterization.
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Treatment of Autoimmune Disease by Intense Immunosuppressive Conditioning and Autologous Hematopoietic Stem Cell Transplantation
Richard K. Burt,Ann E. Traynor,Ann E. Traynor,Ann E. Traynor,Richard M. Pope,Richard M. Pope,Richard M. Pope,James W. Schroeder,James W. Schroeder,James W. Schroeder,Bruce A. Cohen,Bruce A. Cohen,Bruce A. Cohen,Karyn H. Karlin,Karyn H. Karlin,Karyn H. Karlin,Lorri Lobeck,Lorri Lobeck,Lorri Lobeck,Charles L. Goolsby,Charles L. Goolsby,Charles L. Goolsby,Philip Rowlings,Philip Rowlings,Philip Rowlings,Floyd A. Davis,Floyd A. Davis,Floyd A. Davis,Dusan Stefoski,Dusan Stefoski,Dusan Stefoski,Cass Terry,Cass Terry,Cass Terry,Carolyn A. Keever-Taylor,Carolyn A. Keever-Taylor,Carolyn A. Keever-Taylor,Steve Rosen,Steve Rosen,Steve Rosen,David Vesole,David Vesole,David Vesole,M. Fishman,M. Fishman,M. Fishman,Mary Brush,Mary Brush,Mary Brush,Salim Mujias,Salim Mujias,Salim Mujias,M. Villa,M. Villa,M. Villa,William H. Burns,William H. Burns,William H. Burns +57 more
TL;DR: It is concluded that intense immunosuppressive conditioning and autologous T-cell-depleted hematopoietic transplantation was safely used to treat these 10 patients with severe autoimmune disease.
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Reducing cellular autofluorescence in flow cytometry : an in situ method
TL;DR: This work employed a method using the polyanionic azo dye, trypan blue, to reduce intracellular autofluorescence, and realized an approximately 5-fold increase in signal to noise ratio in the direct detection of RNA target probes using flow cytometry.
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NUP98-HOXA9 Induces Long-term Proliferation and Blocks Differentiation of Primary Human CD34+ Hematopoietic Cells
TL;DR: A comprehensive picture is provided of the changes in proliferation, differentiation, and global gene expression that underlie the leukemic transformation of human hematopoietic cells by NUP98-HOXA9.
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T cell-depleted autologous hematopoietic stem cell transplantation for multiple sclerosis: report on the first three patients.
Richard K. Burt,Ann E. Traynor,Bruce A. Cohen,Karyn H. Karlin,Floyd A. Davis,Dusan Stefoski,C. Terry,L. Lobeck,Eric J. Russell,Charles L. Goolsby,Steve Rosen,Leo I. Gordon,Carolyn A. Keever-Taylor,Mary Brush,M. Fishman,William H. Burns +15 more
TL;DR: It is concluded that T cell-depleted hematopoietic stem cell transplantation can be performed safely in patients with severe and debilitating multiple sclerosis and has resulted in modest neurologic improvements for the first time since onset of progressive disease.