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Charles S. Elmore

Researcher at AstraZeneca

Publications -  99
Citations -  1982

Charles S. Elmore is an academic researcher from AstraZeneca. The author has contributed to research in topics: Radioligand & Chemistry. The author has an hindex of 19, co-authored 89 publications receiving 1561 citations. Previous affiliations of Charles S. Elmore include Vanderbilt University & Merck & Co..

Papers
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Journal ArticleDOI

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kelem Kassahun, +9 more
- 01 Jan 2001 - 
TL;DR: The finding that metabolism of the TZD ring of troglitazone was catalyzed selectively by P450 3A enzymes is significant in light of the recent report that trog litazone is an inducer of this isoform in human hepatocytes.
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Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

Emre M. Isin, +4 more
- 28 Feb 2012 - 
TL;DR: The activities of Isotope Chemistry at AstraZeneca is described and a brief overview of different commonly used approaches for the preparation of (14)C- and (3)H-labeled drug candidates are presented with in-house examples where relevant.
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Isotope chemistry; a useful tool in the drug discovery arsenal

Charles S. Elmore, +1 more
- 15 Jan 2015 - 
TL;DR: The methods used to prepare radiolabeled compounds by Isotope Chemists have been reviewed relatively recently, but the organization and utilization of Isotopes has not been discussed recently and will be reviewed herein.
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Metabolism And Excretion of the Dipeptidyl Peptidase 4 Inhibitor [14C]Sitagliptin in Humans

Stella H. Vincent, +14 more
- 01 Apr 2007 - 
TL;DR: The metabolism and excretion of [14C]sitagliptin, an orally active, potent and selective dipeptidyl peptidase 4 inhibitor, were investigated in humans after a single oral dose of 83 mg/193 μCi, indicating that sitagli leptin was eliminated primarily by renal excretion.
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Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.

Federica Sebastiani, +16 more
- 23 Mar 2021 - 
TL;DR: In this article, small-angle neutron scattering was used together with selective lipid, cholesterol, and solvent deuteration to elucidate the structure of the LNP and the distribution of the lipid components in the absence and the presence of apolipoproteinE.