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Charles V. Vorhees
Researcher at University of Cincinnati Academic Health Center
Publications - 346
Citations - 16409
Charles V. Vorhees is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Morris water navigation task & Water maze. The author has an hindex of 58, co-authored 337 publications receiving 14885 citations. Previous affiliations of Charles V. Vorhees include Northern Kentucky University & Food and Drug Administration.
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Journal ArticleDOI
Morris water maze: procedures for assessing spatial and related forms of learning and memory
TL;DR: The Morris water maze has proven to be a robust and reliable test that is strongly correlated with hippocampal synaptic plasticity and NMDA receptor function and trial-dependent, latent and discrimination learning can be assessed using modifications of the basic protocol.
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Assessing spatial learning and memory in rodents.
TL;DR: Several allocentric assessment methods for rodents are reviewed and compared with the Morris water maze and it is concluded that, on balance, the MWM has more advantages than disadvantages and compares favorably with other allocentric navigation tasks.
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Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.
Faisal Adhami,Faisal Adhami,Guanghong Liao,Yury M. Morozov,Aryn Schloemer,Vincent J. Schmithorst,John N. Lorenz,R. Scott Dunn,Charles V. Vorhees,Marsha Wills-Karp,Jay L. Degen,Roger J. Davis,Noboru Mizushima,Pasko Rakic,Bernard J. Dardzinski,Scott K. Holland,Frank R. Sharp,Chia-Yi Kuan +17 more
TL;DR: It is suggested that ischemia-hypoxia is a powerful stimulus for spontaneous coagulation leading to reperfusion deficits and autophagic/lysosomal cell death in brain.
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Hypoxia-Ischemia Induces DNA Synthesis without Cell Proliferation in Dying Neurons in Adult Rodent Brain
Chia-Yi Kuan,Aryn Schloemer,Aigang Lu,Aigang Lu,Kevin A. Burns,Wei Lan Weng,Michael T. Williams,Kenneth I. Strauss,Charles V. Vorhees,Richard A. Flavell,Roger I. Davis,Frank R. Sharp,Pasko Rakic +12 more
TL;DR: The combination of hypoxia and ischemia induces adult rodent neurons to resume DNA synthesis as indicated by incorporation of bromodeoxyuridine (BrdU) and expression of G1/S-phase cell cycle transition markers and the demonstration of neurogenesis after brain injury requires not only BrdU uptake and mature neuronal markers but also evidence showing absence of apoptotic markers.
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Deficiency in Na,K-ATPase α Isoform Genes Alters Spatial Learning, Motor Activity, and Anxiety in Mice
Amy E. Moseley,Michael T. Williams,Tori L. Schaefer,Cynthia S. Bohanan,Jon C. Neumann,Michael M. Behbehani,Charles V. Vorhees,Jerry B. Lingrel +7 more
TL;DR: The learning and memory deficits observed in the α2 and α3 heterozygous mice reveal the Na,K-ATPase to be an important factor in the functioning of pathways associated with spatial learning.