Charles W. Boone

TL;DR: In this paper, the effect of surface-enhanced Raman scattering (SERS) is exploited to detect the native chemical constituents of living cells, such as DNA and phenylalanine.

TL;DR: The current study correlated early biochemical and histologic changes in oral tissue with spectral features in fluorescence, reflectance, and light scattering spectra acquired in vivo to diagnose early stages of oral malignancies.

TL;DR: A remarkable finding is that the spatial correlations over small length scales take the form of an inverse power law, indicating the fractal nature of the packing of the subcellular structures.

TL;DR: In this article, the angular distribution of light backscattered by biological cells and tissues was studied using a novel instrument for imaging the angular distributions of light in biological images, and it was shown that the scattering from subcellular structure in both normal and cancerous human cells is best fitted to inverse power-law distributions for the sizes of the scattering objects.

TL;DR: A model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index is applied to light scattering spectra obtained from excised esophagi of normal and carcinogen-treated rats, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer.