C
Chaussain Jl
Researcher at French Institute of Health and Medical Research
Publications - 22
Citations - 3034
Chaussain Jl is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Precocious puberty & Bone age. The author has an hindex of 10, co-authored 22 publications receiving 2821 citations. Previous affiliations of Chaussain Jl include University of Valladolid.
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Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
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Precocious puberty and statural growth
TL;DR: It is shown that GnRH agonists restore adult height in children when it is compromised by precocious puberty, and the most appropriate time for interrupting the treatment is still controversial.
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Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma
I. Henry,S. Grandjouan,P. Couillin,F. Barichard,Cecile Huerre-Jeanpierre,Thomas M Glaser,T. Philip,Lenoir Gm,Chaussain Jl,Claudine Junien +9 more
TL;DR: Analysis of constitutional and tumor genotypes in nine cases of hereditary Wilms tumor and in three unrelated cases of familial adrenocortical carcinoma suggest that region 11p15.5 may carry a non-tissue-specific gene that could be involved in genetic predisposition, in tumor progression, or in both.
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Gonadotropin and α-Subunit Secretion During Long Term Pituitary Suppression by D-Trp6-Luteinizing Hormone-Releasing Hormone Microcapsules as Treatment of Precocious Puberty*
Najiba Lahlou,Marc Roger,Chaussain Jl,Feinstein Mc,Charles Sultan,J E Toublanc,Andrew V. Schally,Robert Scholler +7 more
TL;DR: The sustained response of Gn alpha to LHRH demonstrates that gonadotroph cell L HRH receptors are still responsive to LhrH during treatment with a LHRh agonist, and the large discrepancy between RIA and IRMA LH values suggests the secretion of unusual LH molecules which are recognized by RIA but not by IRMA.
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Treatment of central precocious puberty by subcutaneous injections of leuprorelin 3-month depot (11.25 mg).
Jean-Claude Carel,Najiba Lahlou,Orlando Jaramillo,Vincent Montauban,Cécile Teinturier,Michel Colle,Christel Lucas,Chaussain Jl +7 more
TL;DR: In conclusion, leuprorelin 3-month depot efficiently inhibits the gonadotropic axis in 95% of children with central precocious puberty studied for a 6-month period, allowing the reduction of the number of yearly injections from 12 to 4.