J
Jean Claude Carel
Researcher at French Institute of Health and Medical Research
Publications - 29
Citations - 4135
Jean Claude Carel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Autoantibody & Growth hormone treatment. The author has an hindex of 17, co-authored 29 publications receiving 3811 citations. Previous affiliations of Jean Claude Carel include Paris Diderot University.
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Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
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Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: Summary statement of the GH research society
Kenneth M. Attie,Bengt-Åke Bengtsson,Sandra L. Blethen,Werner F. Blum,Fergus J. Cameron,Jean Claude Carel,Lena M. S. Carlsson,John J. Chipman,Jens Sandahl Christiansen,Peter E. Clayton,David R. Clemmons,Pinchas Cohen,Stenvert L. S. Drop,Kenji Fujieda,Ezio Ghigo,Raymond L. Hintz,Ken K. Y. Ho,Mbelenge Mapoko Ilondo,Hector Jasper,Bernd Jesussek,Anne Marie Kappelgaard,Zvi Laron,Barbara Lippe,Saul Malozowski,Primus E. Mullis,Sabine M P F de MuinckKeizer-Schrama,Yoshikazu Nishi,John S. Parks,Charlotte Phelps,Michael B. Ranke,Iain C.A.F. Robinson,Ron G. Rosenfeld,Susan R. Rose,Paul Saenger,Guissepe Saggese,Martin O. Savage,Stephen M Shalet,Pierre C. Sizonenko,Christian J. Strasburger,Katsuhiko Tachibana,Toshiaki Tanaka,Michael O. Thorner,Kerstin Albertsson Wikland,Zvi Zadik +43 more
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GNAS1 lesions in pseudohypoparathyroidism Ia and Ic: genotype phenotype relationship and evidence of the maternal transmission of the hormonal resistance.
TL;DR: In the patient diagnosed with PHP-Ic, G(s)alpha protein was shortened by just four amino acids, a finding consistent with the conservation of G (s) activity in erythrocytes and the loss of receptor contact.
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Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study.
Anthony J. Swerdlow,Anthony J. Swerdlow,Rosie Cooke,Dominique Beckers,Birgit Borgström,Gary Butler,Jean Claude Carel,Stefano Cianfarani,Stefano Cianfarani,Peter E. Clayton,Joë L. Coste,Annalisa Deodati,Emmanuel Ecosse,Ruth Gausche,Claudio Giacomozzi,Anita C. S. Hokken-Koelega,Aysha J. Khan,Wieland Kiess,Claudia E. Kuehni,Primus E. Mullis,Roland Pfäffle,Lars Sävendahl,Grit Sommer,Muriel Thomas,Anders Tidblad,Sally Tollerfield,Liesbet Van Eycken,Gladys R J Zandwijken +27 more
TL;DR: The results do not generally support a carcinogenic effect of r-hGH, but the unexplained trend in cancer mortality risk in relation to GH dose in patients with previous cancer, and the indication of possible effects on bone cancer, bladder cancer and HL risks, need further investigation.
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Kallmann’s Syndrome: A Comparison of the Reproductive Phenotypes in Men Carrying KAL1 and FGFR1/KAL2 Mutations
Sylvie Salenave,Philippe Chanson,H. Bry,Michel Pugeat,Sylvie Cabrol,Jean Claude Carel,Arnaud Murat,P. Lecomte,Sylvie Brailly,Jean-Pierre Hardelin,Catherine Dodé,Jacques Young +11 more
TL;DR: KAL1 mutations result in a more severe reproductive phenotype than FGFR1/KAL2 mutations, and the latter are associated with a broader spectrum of pubertal development and with less severe impairment of gonadotropin secretion.