Chek Meng Poh

TL;DR: Two immunodominant regions on the spike glycoprotein that were highly recognized by neutralizing antibodies in the sera of COVID-19 convalescent patients are presented, one is highly specific to SARS-CoV-2, and the other is a potential pan-coronavirus target.

TL;DR: A 2-d protocol to detect cross-presentation by isolating the brain microvessels and incubating them with a reporter cell line that expresses lacZ upon detection of the relevant peptide–major histocompatibility complex is described.

TL;DR: Examination of the mechanisms of immunity behind long-term CD8+ T cell-meditated protection in PD-1KO mice showed a key role for parasite-specific CD8- T cells even when CD4+ T cells and B cells responded to re-infection.

TL;DR: It is shown that concurrent co‐infection induced the most prominent changes in ECM manifestation and averts all downstream pathogenic events such as parasite sequestration in the brain and disruption of blood–brain barrier that prevents ECM‐induced mortality in co‐ infected mice.

TL;DR: In this paper, the authors found that cross-reactivity occurs at the functional level of the humoral response on both the S-CoV-2 S protein variants, which suggests that existing serological assays will be able to detect both D614 and G-614 clades of SARS CoV2 more importantly, there should be negligible impact towards the efficacy of antibody-based therapies and vaccines that are currently being developed.