B
Barnaby Edward Young
Researcher at Tan Tock Seng Hospital
Publications - 177
Citations - 11728
Barnaby Edward Young is an academic researcher from Tan Tock Seng Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 35, co-authored 126 publications receiving 6729 citations. Previous affiliations of Barnaby Edward Young include National University of Singapore & Nanyang Technological University.
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Journal ArticleDOI
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.
Barnaby Edward Young,Sean Wei Xiang Ong,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,Seow Yen Tan,Jiashen Loh,Oon Tek Ng,Kalisvar Marimuthu,Li Wei Ang,Tze Minn Mak,Sok Kiang Lau,Danielle E. Anderson,Kian Sing Chan,Thean Yen Tan,Thean Yen Tan,Tong Yong Ng,Lin Cui,Zubaidah Said,Lalitha Kurupatham,Mark I-Cheng Chen,Monica Chan,Shawn Vasoo,Lin-Fa Wang,Boon Huan Tan,Raymond T. P. Lin,Vernon J. Lee,Yee Sin Leo,David C. Lye +29 more
TL;DR: Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection and some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent.
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A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2-spike protein-protein interaction.
Chee Wah Tan,Wan Ni Chia,Xijian Qin,Pei Liu,Mark I-Cheng Chen,Charles Tiu,Zhiliang Hu,Zhiliang Hu,Vivian Chih Wei Chen,Barnaby Edward Young,Barnaby Edward Young,Wan Rong Sia,Yee-Joo Tan,Yee-Joo Tan,Randy Foo,Yongxiang Yi,David C. Lye,Danielle E. Anderson,Lin-Fa Wang +18 more
TL;DR: A blocking assay based on the recombinant receptor-binding domain of SARS-CoV-2 spike protein and human angiotensin-converting enzyme 2 receptor provides an alternative to conventional antibody neutralization assays requiring live virus.
Journal ArticleDOI
Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients.
Po Ying Chia,Po Ying Chia,Kristen K. Coleman,Yian Kim Tan,Sean Wei Xiang Ong,Marcus Gum,Sok Kiang Lau,Xiao Fang Lim,Ai Sim Lim,Stephanie Sutjipto,Pei Hua Lee,Barnaby Edward Young,Barnaby Edward Young,Donald K. Milton,Gregory C. Gray,Gregory C. Gray,Stephan C. Schuster,Timothy Barkham,Timothy Barkham,Partha Pratim De,Partha Pratim De,Shawn Vasoo,Shawn Vasoo,Monica Chan,Brenda Ang,Boon Huan Tan,Yee Sin Leo,Oon Tek Ng,Oon Tek Ng,Michelle Su Yen Wong,Kalisvar Marimuthu,Kalisvar Marimuthu +31 more
TL;DR: Air and surfaces in hospital rooms of COVID-19 patients are sampled, SARS-CoV-2 RNA is detected in air samples of two of three tested airborne infection isolation rooms, and surface contamination is found in 66.7% of tested rooms during the first week of illness and 20% beyond the first month of illness.
Journal ArticleDOI
Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures.
Rachael Pung,Calvin J Chiew,Barnaby Edward Young,Sarah Chin,Mark I-Cheng Chen,Hannah E. Clapham,Alex R. Cook,Sebastian Maurer-Stroh,Sebastian Maurer-Stroh,Matthias Paul Han Sim Toh,Cuiqin Poh,Mabel Low,Joshua Lum,Valerie T J Koh,Tze M. Mak,Lin Cui,Raymond T. P. Lin,Derrick Heng,Yee Sin Leo,David C. Lye,Vernon J. Lee,Kai Qian Kam,Shirin Kalimuddin,Seow Yen Tan,Jiashen Loh,Koh Cheng Thoon,Shawn Vasoo,Shawn Vasoo,Wei Xin Khong,Nur Afidah Suhaimi,Sherlynn Jh Chan,Emma Zhang,Olivia Seen Huey Oh,Albert Ty,Charlene Tow,Yi Xian Chua,Wei Liang Chaw,Yixiang Ng,Farid Abdul-Rahman,Shafiq Sahib,Zheng Zhao,Cheryl Tang,Constance Low,Ee Hui Goh,Georgina Lim,Yan'an Hou,Imran Roshan,James Tan,Kelly Foo,Khine Nandar,Lalitha Kurupatham,Pei Pei Chan,Pream Raj,Yijun Lin,Zubaidah Said,Anne Lee,Cherie See,Jessey Markose,Joanna Tan,Guanhao Chan,Wanhan See,Xinyi Peh,Vincent Cai,Wen Kai Chen,Zongbin Li,Roy Jiunn Jye Soo,Angela Lp Chow,Wycliffe E. Wei,Aysha Farwin,Li Wei Ang +69 more
TL;DR: SARS-CoV-2 is transmissible in community settings, and local clusters of COVID-19 are expected in countries with high travel volume from China before the lockdown of Wuhan and institution of travel restrictions.
Journal ArticleDOI
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients.
Anthony T. Tan,Martin Linster,Chee Wah Tan,Nina Le Bert,Wan Ni Chia,Kamini Kunasegaran,Yan Zhuang,Christine Y.L. Tham,Adeline Chia,Gavin J. D. Smith,Barnaby Edward Young,Shirin Kalimuddin,Shirin Kalimuddin,Jenny G. Low,Jenny G. Low,David C. Lye,Lin-Fa Wang,Antonio Bertoletti,Antonio Bertoletti +18 more
TL;DR: In this article, the authors quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T-cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins.