C
Chen Chang
Researcher at Academia Sinica
Publications - 9
Citations - 2918
Chen Chang is an academic researcher from Academia Sinica. The author has contributed to research in topics: Diffusion MRI & In vivo. The author has an hindex of 9, co-authored 9 publications receiving 2737 citations. Previous affiliations of Chen Chang include University of Massachusetts Medical School.
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Journal ArticleDOI
Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water
Sheng-Kwei Song,Shu-Wei Sun,Shu-Wei Sun,Michael J. Ramsbottom,Chen Chang,John H. Russell,Anne H. Cross +6 more
TL;DR: The use of magnetic resonance diffusion tensor imaging to quantify the effect of dysmyelination on water directional diffusivities in brains of shiverer mice in vivo suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury.
Journal ArticleDOI
A fMRI study of brain activations during non-noxious and noxious electrical stimulation of the sciatic nerve of rats
Chen Chang,Bai-Chuang Shyu +1 more
TL;DR: The present findings demonstrated that the difference of the innocuous and nociceptive responses in the brain could be detected and localized by an in vivo spatial map using fMRI, suggesting that fMRI may be an invaluable tool for studying pain in anesthetized animals.
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Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats. Evaluation with serial magnetic resonance imaging.
TL;DR: A delayed increase in both CBF and CBV is documented in the ipsilateral cortex after transient focal brain ischemia, and such an increase may be associated with angiogenesis.
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Neuroprotective effect of lamotrigine and MK-801 on rat brain lesions induced by 3-nitropropionic acid: evaluation by magnetic resonance imaging and in vivo proton magnetic resonance spectroscopy
TL;DR: It is concluded that both lamotrigine and MK-801 are effective in attenuation of brain lesions induced by 3-nitropropionic acid and a higher dose of lamotigine provides a better neuroprotective effect than MK-802.
Journal ArticleDOI
Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion.
Teng-Nan Lin,Gau Ming Nian,Shu Fen Chen,Wai Mui Cheung,Chen Chang,Wen-chang Lin,Chung Y. Hsu +6 more
TL;DR: The findings suggest that the evolving expression of angiogenesis genes underlie the robust vascular remodeling after ischemia and reperfusion in endothelial cells in different regions.