S
Sheng-Kwei Song
Researcher at Washington University in St. Louis
Publications - 157
Citations - 16879
Sheng-Kwei Song is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Diffusion MRI & White matter. The author has an hindex of 56, co-authored 157 publications receiving 15398 citations. Previous affiliations of Sheng-Kwei Song include University of Alabama at Birmingham & University of Washington.
Papers
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Journal ArticleDOI
Dysmyelination Revealed through MRI as Increased Radial (but Unchanged Axial) Diffusion of Water
Sheng-Kwei Song,Shu-Wei Sun,Shu-Wei Sun,Michael J. Ramsbottom,Chen Chang,John H. Russell,Anne H. Cross +6 more
TL;DR: The use of magnetic resonance diffusion tensor imaging to quantify the effect of dysmyelination on water directional diffusivities in brains of shiverer mice in vivo suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury.
Journal ArticleDOI
Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia.
TL;DR: The hypothesis that lambdaparallel and lambdaperpendicular hold promise as specific markers of axonal and myelin injury, respectively, and, further, that the coexistence of axon andMyelin degeneration does not confound this utility, are supported.
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Demyelination increases radial diffusivity in corpus callosum of mouse brain.
Sheng-Kwei Song,Jun E. Yoshino,Jun E. Yoshino,Tuan Q. Le,Shiow Jiuan Lin,Shu-Wei Sun,Anne H. Cross,Regina C. Armstrong,Regina C. Armstrong +8 more
TL;DR: In this article, the authors used diffusion tensor imaging (DTI) derived parameters to assess the extent of axonal damage, demyelination and axonal degeneration.
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Axial Diffusivity Is the Primary Correlate of Axonal Injury in the Experimental Autoimmune Encephalomyelitis Spinal Cord: A Quantitative Pixelwise Analysis
TL;DR: A strong, quantitative relationship between axial diffusivity and axonal damage is demonstrated and anisotropy is not specific for axonalDamage after inflammatory demyelination, demonstrating the lack of specificity of conventional, relaxivity-based MRI measurements in detecting axonal injury.
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Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
Shu-Wei Sun,Hsiao-Fang Liang,Kathryn Trinkaus,Anne H. Cross,Regina C. Armstrong,Sheng-Kwei Song +5 more
TL;DR: The results suggest that λ∥ and λ⟂ may be useful in vivo surrogate markers of axonal and myelin damage in mouse CNS white matter and may be modulated in the presence ofAxonal damage during the early stage of demyelination at 4 weeks of cuprizone treatment.