C
Chen-Chi Chien
Researcher at University of Pennsylvania
Publications - 9
Citations - 334
Chen-Chi Chien is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Turbulence & Constant (mathematics). The author has an hindex of 6, co-authored 7 publications receiving 233 citations. Previous affiliations of Chen-Chi Chien include Wesleyan University.
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Journal ArticleDOI
Measurement of DNA Translocation Dynamics in a Solid-State Nanopore at 100 ns Temporal Resolution
Siddharth Shekar,David J. Niedzwiecki,Chen-Chi Chien,Peijie Ong,Daniel A. Fleischer,Jianxun Lin,Jacob K. Rosenstein,Marija Drndic,Kenneth L. Shepard +8 more
TL;DR: A complementary metal-oxide-semiconductor nanopore (CNP) amplifier capable of low noise recordings at an unprecedented 10 MHz bandwidth and an SNR of greater than 10 for ssDNA translocations at a measurement bandwidth of 5 MHz, which represents the fastest ion current recordings through nanopores reported to date.
Journal ArticleDOI
Single-Stranded DNA Translocation Recordings through Solid-State Nanopores on Glass Chips at 10 MHz Measurement Bandwidth.
TL;DR: This work demonstrates detection of translocation events as brief as 100 ns with a signal-to-noise ratio exceeding seven at a measurement bandwidth of 10 MHz, and shows that characteristic translocation rates are at least ten times faster than previously recorded.
Journal ArticleDOI
Suspended Solid-state Membranes on Glass Chips with Sub 1-pF Capacitance for Biomolecule Sensing Applications
TL;DR: An integrated fabrication process is devised to grow and define circular silicon nitride membranes on glass chips that successfully lower the chip capacitance to below 1 pF and makes use of this versatile, low-capacitance platform to suspend other thin, two-dimensional membrane such as graphene.
Journal ArticleDOI
Periodic Arrays of Phosphorene Nanopores as Antidot Lattices with Tunable Properties
Andrew Cupo,Paul Masih Das,Chen-Chi Chien,Gopinath Danda,Neerav Kharche,Damien Tristant,Marija Drndic,Vincent Meunier +7 more
TL;DR: This work fabricated antidot lattices with radii down to 13 nm in few-layer black phosphorus flakes protected by an oxide layer and observed suppression of the in-plane phonon modes relative to the unmodified material via Raman spectroscopy.
Journal ArticleDOI
Wavelet Denoising of High-Bandwidth Nanopore and Ion-Channel Signals.
Siddharth Shekar,Chen-Chi Chien,Andreas J.W. Hartel,Peijie Ong,Oliver B. Clarke,Andrew R. Marks,Marija Drndic,Kenneth L. Shepard +7 more
TL;DR: Improvements to the SNR that can be achieved using wavelet denoising instead of Bessel filtering can be used to achieve robust statistical analyses of these recordings, which may provide important insights into nanopore translocation dynamics and mechanisms of ion channel function.