The invention provides a new preparation method of a 2-substituted benzothiazole compound, relating to the field of organic synthesis chemistry. According to the new preparation method, in existence of catalyst, oxidant and additive, methylbenzene or a derivative thereof reacts with o-aminothiophenol through free radial reaction so as to prepare the 2-substituted benzothiazole compound in one step. The new method is an example but not limited and has the beneficial effects that methylbenzene or a derivative thereof and o-aminothiophenol construct a C-S bond and a C-N bond through the free radical method for the first time so as to generate the 2-substituted benzothiazole by coupling reaction in one step, and the new preparation method has advantages that the method is efficient, concise and environmentally friendly, raw materials are easy to obtain, and the product purity is high and the like, and the method has good application value and research prospects.

New preparation method of 2-substituted benzothiazole compound

The invention relates to a method for synthesizing a diaryl pyrrole compound. The method comprises a reaction route shown in the specification. The method comprises the following steps: S1, in the presence of a palladium catalyst, organic ligand, an oxidant and an acid compound, enabling a compound of formula (I) and a compound of formula (2) to react in an organic solvent, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (3); S2, in the organic solvent, enabling the compound of formula (3) to be subjected to a self-cyclization reaction in thepresence of the oxidant, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (4); S3, in the presence of nitrogen, enabling the compound of formula (4)and a compound of formula (5) to react in the solvent in the presence of the palladium catalyst, the organic ligand, the oxidant and the acid compound, and performing aftertreatment after the reaction is completed so as to obtain a compound of formula (6). By adopting the method, different steps are creatively optimized with multiple technical characteristics, completely new synthesis methods andsynthesis routes are provided for preparation of the compound, and good industrial prospects and potential application values can be achieved.

Method for synthesizing diaryl pyrrole compound

The invention relates to a method for the catalytic synthesis of a 2-substituted benzothiazole compound by utilizing a Yb/MCM-41 molecular sieve-based catalyst. The method comprises the steps of (a) subjecting 2-amino thiophenol, an aldehyde compound and a Yb/MCM-41 molecular sieve-based catalyst to agitation backflow in an organic solvent at 70 to 90 DEG C for 4-5 hours to obtain a solid-liquid mixture; (b) filtering the solid-liquid mixture obtained in the step (a) to obtain a solid-state product Yb/MCM-41 molecular sieve-based catalyst, recycling and subjecting the filtrate to column chromatography separation, and obtaining the 2-substituted benzothiazole compound after the separating and purifying process. compared with the prior art, the method is mild in reaction condition, simple in operation, high in yield and good in universality. Meanwhile, the catalyst can be recycled.

Method for catalytic synthesis of 2-substituted benzothiazole compound by utilizing Yb/MCM-41 molecular sieve-based catalyst

The invention relates to a synthesis method of an anti-tumor medicine compound, namely a compound shown as the formula (V) A total synthesis route of the synthesis method is shown as the description According to the method provided by the invention, a specific reaction step is carried out; especially in step 1, a catalyst, a nitrogen-containing ligand, an acidic additive and a solvent are comprehensively selected and synergized, so that a brand-new route for synthesizing the anti-tumor medicine compound is obtained and the total yield is high; the source of raw materials is widened and synthesis routes are enriched; the synthesis method has a good application prospect and a good production potential

Synthesis method of anti-tumor medicine compound

The invention relates to a method for synthesizing a pyrrole derivative represented by a formula (6) shown in the description The synthesis method has a reaction route shown in the description The synthesis method comprises the following steps: S1: subjecting a compound represented by a formula (3) shown in the description to a self-cyclization reaction in the presence of an oxidant in an organic solvent, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (4) shown in the description; and S2: subjecting the compound represented by theformula (4) and a compound represented by a formula (5) shown in the description to a reaction in the presence of a palladium catalyst, an organic ligand and an acidic compound in a solvent in a nitrogen atmosphere, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (6) shown in the description According to the method, through creativelyoptimizing a plurality of technical features of each step, a bran-new synthesis method and synthesis route are provided for preparing this kind of compounds, and thus, the method has a good industrialization prospect and a potential application value

Method for synthesizing pyrrole derivative

The invention relates to a synthesis method of benzothiazole derivatives, which comprises the following step: in an organic solvent, reacting hydroxyketone compounds and 2-aminothiophenol in the presence of a catalyst and an optional accelerator to synthesize the benzothiazole derivatives. The method has the advantages of high yield, high purity, simple after-treatment and the like, provides a new route and method for synthesis of the benzothiazole derivatives, and has favorable potential applications and research value.

Synthesis method of benzothiazole derivatives

The invention relates to a preparation method of an isoquinoline derivative. The method comprises the step that a dinitrile compound and aryl triborofluoride are reacted in a solvent and in the presence of a palladium catalyst, a containing N-donor ligand and an accelerant to obtain an isoquinoline compound. The method is simple in reaction, simple and convenient to operate and high in yield, and is a brand-new synthesis method of the isoquinoline compound; a new synthesis line is provided for the preparation of such compound; the scientific research value and industrial potential are high.

Preparation method of isoquinoline derivative

The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.

Method for synthesizing indole derivative

The invention relates to a synthesis method of aryl ketone compounds, which comprises the following step: in a reaction solvent, reacting nitrile compounds with aryl boric acid in the presence of a palladium catalyst, a ligand and an accelerator to obtain the aryl ketone compounds. The method has the advantages of simple reaction and high yield, is simple to operate, is a brand-new synthesis method of aryl ketone compounds, provides a new synthesis route for synthesis of the aryl ketone compounds, and has favorable scientific research value and industrialization potential.

Synthesis method of aryl ketone compounds

The invention relates to a synthesis method of asymmetric diaryl substituted butanedione compounds disclosed as Formula (III). The method comprises the following steps: in a solvent, carrying out reaction on compounds disclosed as Formula (I) and compounds disclosed as Formula (II) in the presence of a catalyst, a ligand and an acidic compound; and after the reaction finishes, carrying out after-treatment, thereby obtaining the compounds disclosed as Formula (III), wherein R is halogen, C1-C6 alkyl or C1-C6 alkoxy, and X is an alkali metal element. Under the combined selection and synergic actions of the specific catalyst, ligand, acidic compound and solvent, the method can obtain the asymmetric diaryl substituted butanedione compounds at high yield, and has favorable application prospects and industrial production potential in the field of organic chemical synthesis. Besides, the invention also relates to a synthesis method of the raw material compounds disclosed as Formula (I) and researches the optimal synthesis conditions and technical characteristics.

Wu Huayue

Papers

Synthesis method of benzothiazole derivatives

Preparation method of isoquinoline derivative

Method for synthesizing indole derivative

Synthesis method of aryl ketone compounds

Synthesis method of asymmetric diaryl substituted butanedione compounds