C
Cheng Huang
Researcher at University of Texas Medical Branch
Publications - 64
Citations - 4185
Cheng Huang is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Virus & Coronavirus. The author has an hindex of 27, co-authored 59 publications receiving 3326 citations. Previous affiliations of Cheng Huang include Hiroshima University.
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Differential immune responses to hemorrhagic Fever-Causing arenaviruses
TL;DR: Recent findings about interactions of these pathogenic arenaviruses with the innate immune machinery and the subsequent effects on adaptive immunity are summarized to inform the development of vaccines and therapeutics against arenavirus infections.
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Identification of mutations associated with attenuation of virulence of a field Sendai virus isolate by egg passage.
Yutaka Fujii,Takemasa Sakaguchi,Katsuhiro Kiyotani,Cheng Huang,Noriko Fukuhara,Tetsuya Yoshida +5 more
TL;DR: To determine the molecular basis for the attenuation of SeV pathogenicity by egg passage, entire genomes of representative SeV clones isolated during egg passages were sequenced and the significance of the mutations detected in the leader as well as in the L and HN genes was discussed.
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Alteration of Sendai Virus Morphogenesis and Nucleocapsid Incorporation due to Mutation of Cysteine Residues of the Matrix Protein
Takemasa Sakaguchi,Tsuneo Uchiyama,Cheng Huang,Noriko Fukuhara,Katsuhiro Kiyotani,Yoshiyuki Nagai,Tetsuya Yoshida +6 more
TL;DR: Results indicate that a single-point mutation at a cysteine residue of the M protein affects virus morphology and nucleocapsid incorporation, showing direct involvement of theM protein in SeV assembly.
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Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
TL;DR: A confocal microscopy protocol is described that has been used successfully to visualize dsRNA, viral protein and PRR simultaneously in individual cells infected by arenavirus and is suitable for imaging studies of ds RNA andPRR distribution in pathogenic werenavirus infected cells in BSL4 facilities.
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The Ectodomain of Glycoprotein from the Candid#1 Vaccine Strain of Junin Virus Rendered Machupo Virus Partially Attenuated in Mice Lacking IFN-αβ/γ Receptor
Takaaki Koma,Cheng Huang,Judith F. Aronson,Aida G. Walker,Milagros Miller,Jeanon N. Smith,Michael Patterson,Slobodan Paessler +7 more
TL;DR: The data suggest the indispensable role of each GPC domain in the full attenuation and immunogenicity of rMACV/Cd#1 GPC.