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Cheng Yang Wu
Researcher at University of Texas Southwestern Medical Center
Publications - 12
Citations - 543
Cheng Yang Wu is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Pyruvate dehydrogenase complex & Pyruvate decarboxylation. The author has an hindex of 9, co-authored 10 publications receiving 366 citations. Previous affiliations of Cheng Yang Wu include Academia Sinica.
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Journal ArticleDOI
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance.
Meiyi Zhou,Jing Shao,Cheng Yang Wu,Le Shu,Weibing Dong,Yunxia Liu,Mengping Chen,R. Max Wynn,Jiqiu Wang,Ji Wang,Wen Jun Gui,Xiangbing Qi,Aldons J. Lusis,Zhaoping Li,Weiqing Wang,Guang Ning,Xia Yang,David T. Chuang,Yibin Wang,Haipeng Sun,Haipeng Sun +20 more
TL;DR: Data demonstrate a pivotal causal role of a BCAA catabolic defect and elevated abundance of BCAAs and BCKAs in obesity-associated IR and provide proof-of-concept evidence for the therapeutic validity of manipulating BCAA metabolism for treating diabetes.
Journal ArticleDOI
Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket
Shih Chia Tso,Xiangbing Qi,Wen Jun Gui,Cheng Yang Wu,Jacinta L. Chuang,Ingrid Wernstedt-Asterholm,Lorraine Morlock,Kyle R. Owens,Philipp E. Scherer,Noelle S. Williams,Uttam K. Tambar,R. Max Wynn,David T. Chuang +12 more
TL;DR: The pharmacological approach of targeting PDK to control both glucose and fat levels in obesity and type 2 diabetes is supported, and obesity phenotypes are effectively treated by chemical intervention with PDK inhibitors.
Journal ArticleDOI
Photophysical studies of anion-induced colorimetric response and amplified fluorescence quenching in dipyrrolylquinoxaline-containing conjugated polymers.
Cheng Yang Wu,Min-Shen Chen,Min-Shen Chen,Min-Shen Chen,Chih-An Lin,Su-Ching Lin,Shih-Sheng Sun +6 more
TL;DR: The dipyrrolylquinoxaline-containing monomer and polymers were synthesized and employed as chromogenic and fluorescent chemosensors for inorganic anions and it is found that in the presence of fluoride or pyrophosphate, the receptors do not form hydrogen bonds between the pyrrole protons and anions.
Journal ArticleDOI
Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase
Shih Chia Tso,Wen Jun Gui,Cheng Yang Wu,Jacinta L. Chuang,Xiangbing Qi,Kristen J. Skvorak,Kenneth Dorko,Amy L. Wallace,Lorraine Morlock,Brendan Lee,Susan M. Hutson,Stephen C. Strom,Noelle S. Williams,Uttam K. Tambar,R. Max Wynn,David T. Chuang +15 more
TL;DR: These benzothiophene carboxylate derivatives are allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase (BDK) that robustly augment BCAA oxidation in mice, resulting in lower plasma BCAA.
Journal ArticleDOI
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.
Cheng Yang Wu,Shih Chia Tso,Jacinta L. Chuang,Wen Jun Gui,Mingliang Lou,Gaurav Sharma,Chalermchai Khemtong,Xiangbing Qi,R. Max Wynn,David T. Chuang +9 more
TL;DR: It is established that specific targeting of hepatic PDKs with the PDK inhibitor PS10 is an effective therapeutic approach to maintaining glucose and lipid homeostasis in obesity and T2D, without the harmful ketoacidosis associated with systemic inhibition of PDKS.