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David T. Chuang
Researcher at University of Texas Southwestern Medical Center
Publications - 120
Citations - 5197
David T. Chuang is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Maple syrup urine disease & Pyruvate dehydrogenase complex. The author has an hindex of 41, co-authored 119 publications receiving 4590 citations. Previous affiliations of David T. Chuang include University of Texas at Austin & University of Texas at Dallas.
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Journal ArticleDOI
Catabolic defect of branched-chain amino acids promotes heart failure
Haipeng Sun,Haipeng Sun,Kristine C. Olson,Chen Gao,Domenick A. Prosdocimo,Meiyi Zhou,Zhihua Wang,Darwin Jeyaraj,Ji Youn Youn,Shuxun Ren,Yunxia Liu,Christoph Rau,Svati H. Shah,Olga Ilkayeva,Wen Jun Gui,Noelle S. William,R. Max Wynn,Christopher B. Newgard,Hua Cai,Xinshu Xiao,David T. Chuang,Paul Christian Schulze,Paul Christian Schulze,Christopher J. Lynch,Mukesh K. Jain,Yibin Wang,Yibin Wang +26 more
TL;DR: BCAA catabolic defect is a metabolic hallmark of failing heart resulting from Krüppel-like factor 15–mediated transcriptional reprogramming, and pharmacological enhancement of branched-chain &agr;-keto acid dehydrogenase activity significantly blunted cardiac dysfunction after pressure overload.
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Seeing GroEL at 6 Å Resolution by Single Particle Electron Cryomicroscopy
TL;DR: A reconstruction of native GroEL by electron cryomicroscopy (cryo-EM) and single particle analysis at 6 A resolution and a measurable shift in the positions of three alpha helices in the intermediate domain is observed, not consistent with any of the 7 monomeric structures in the Protein Data Bank model (1OEL).
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Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol
TL;DR: Structures of human PDK1 or PDK3 bound to the inhibitors AZD7545, dichloroacetate (DCA), and radicicol are determined and it is shown that the trifluoromethylpropanamide end of AZD 7545 projects into the lipoyl-binding pocket of PDK 1, leading to inhibition ofPDK1 andPDK3 activities by aborting kinase binding to the PDC scaffold.
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De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy.
TL;DR: It is demonstrated that it is possible to achieve a de novo Calpha trace directly from a cryo-EM reconstruction of GroEL, and the topology of the backbone trace is completely accurate, though subtle alterations illustrate significant differences from existing crystal structures.
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
Phillip J. White,Phillip J. White,Robert W. McGarrah,Robert W. McGarrah,Paul A. Grimsrud,Shih Chia Tso,Wen-Hsuan Yang,Jonathan M. Haldeman,Grenier-Larouche Thomas,Jie An,Amanda L. Lapworth,Inna Astapova,Inna Astapova,Sarah A. Hannou,Tabitha George,Michelle Arlotto,Lyra B. Olson,Michelle Lai,Guo-Fang Zhang,Guo-Fang Zhang,Olga Ilkayeva,Mark A. Herman,Mark A. Herman,R. Max Wynn,David T. Chuang,Christopher B. Newgard,Christopher B. Newgard +26 more
TL;DR: These studies identify BDK and PPM1K as a ChREBP-regulated node that integrates BCAA and lipid metabolism and manipulation of the BDK:P PM1K ratio relieves key metabolic disease phenotypes in a genetic model of severe obesity.