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Chengyuan Tang
Researcher at Central South University
Publications - 84
Citations - 3631
Chengyuan Tang is an academic researcher from Central South University. The author has contributed to research in topics: Acute kidney injury & Medicine. The author has an hindex of 26, co-authored 63 publications receiving 1892 citations.
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Journal ArticleDOI
The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1
Li Xiao,Xiaoxuan Xu,Fan Zhang,Ming Wang,Yan Xu,Dan Tang,Jiahui Wang,Yan Qin,Yu Liu,Chengyuan Tang,Liyu He,Anna Greka,Zhiguang Zhou,Fuyou Liu,Zheng Dong,Lin Sun +15 more
TL;DR: It is suggested that mitoQ exerts beneficial effects on tubular injury in DKD via mitophagy and that mitochondrial quality control is mediated by Nrf2/PINK.
Journal ArticleDOI
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
Yachun Han,Xiaoxuan Xu,Chengyuan Tang,Peng Gao,Xianghui Chen,Xiaofen Xiong,Ming Yang,Shikun Yang,Xuejing Zhu,Shuguang Yuan,Fuyou Liu,Li Xiao,Yashpal S. Kanwar,Lin Sun +13 more
TL;DR: The results suggest that mitochondrial ROS-TXNIP/NLRP3/IL-1β axis activation is responsible for tubular oxidative injury, which can be ameliorated by MitoQ via the inhibition of mtROS overproduction.
Journal ArticleDOI
Autophagy in kidney homeostasis and disease.
TL;DR: The authors summarize the basics of autophagy and the signalling pathways involved in its regulation, and examine the multiple roles of autophile in kidney cells, from its involvement in kidney maintenance and responses to injury, to its potential contribution to glomerular and tubulointerstitial disease.
Journal ArticleDOI
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury
Chengyuan Tang,Hailong Han,Mingjuan Yan,Shiyao Zhu,Jing Liu,Zhiwen Liu,Liyu He,Jieqiong Tan,Yu Liu,Hong Liu,Lin Sun,Shao-Bin Duan,Youming Peng,Fuyou Liu,Xiao Ming Yin,Zhuohua Zhang,Zheng Dong +16 more
TL;DR: It is shown thatmitophagy is induced in renal proximal tubular cells in both in vitro and in vivo models of ischemic AKI, indicating that PINK1-PARK2-mediated mitophagy plays an important role in mitochondrial quality control, tubular cell survival, and renal function during AKI.
Journal ArticleDOI
Mitochondrial quality control in kidney injury and repair.
Chengyuan Tang,Juan Cai,Xiao Ming Yin,Joel M. Weinberg,Manjeri A. Venkatachalam,Zheng Dong,Zheng Dong +6 more
TL;DR: The role of mitochondrial quality control mechanisms in kidney injury and repair is discussed and their potential as therapeutic targets are highlighted.