J
Jieqiong Tan
Researcher at Central South University
Publications - 99
Citations - 2370
Jieqiong Tan is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Autophagy. The author has an hindex of 18, co-authored 67 publications receiving 1353 citations.
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Journal ArticleDOI
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury
Chengyuan Tang,Hailong Han,Mingjuan Yan,Shiyao Zhu,Jing Liu,Zhiwen Liu,Liyu He,Jieqiong Tan,Yu Liu,Hong Liu,Lin Sun,Shao-Bin Duan,Youming Peng,Fuyou Liu,Xiao Ming Yin,Zhuohua Zhang,Zheng Dong +16 more
TL;DR: It is shown thatmitophagy is induced in renal proximal tubular cells in both in vitro and in vivo models of ischemic AKI, indicating that PINK1-PARK2-mediated mitophagy plays an important role in mitochondrial quality control, tubular cell survival, and renal function during AKI.
Journal ArticleDOI
BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy.
Tongmei Zhang,Liang Xue,Li Li,Chengyuan Tang,Zhengqing Wan,Ruoxi Wang,Jieqiong Tan,Ya Tan,Hailong Han,Runyi Tian,Timothy R. Billiar,Timothy R. Billiar,W. Andy Tao,Zhuo-Hua Zhang,Zhuo-Hua Zhang +14 more
TL;DR: It is demonstrated that BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3), a mitochondrial BH3-only protein, interacts with PINK1 to promote the accumulation of full-length Pink1 on the outer membrane of mitochondria, which facilitates parkin recruitment and PINK 1/parkin-mediated mitophagy.
Journal ArticleDOI
Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.
Jia-Hong Lu,Jieqiong Tan,Siva Sundara Kumar Durairajan,Liang-Feng Liu,Zhuohua Zhang,Long Ma,Han-Ming Shen,H. Y.Edwin Chan,Min Li +8 more
TL;DR: Data from this study raise the possibility that oxindole alkaloid derivatives may serve as a means to stimulate autophagy in neuronal cells, thereby exerting preventive and therapeutic values against neurodegenerative diseases such as Parkinson disease by reducing pathogenic protein aggregates in neurons.
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Regulation of Intracellular Manganese Homeostasis by Kufor-Rakeb Syndrome-associated ATP13A2 Protein
Jieqiong Tan,Tongmei Zhang,Li Jiang,Jingwei Chi,Dongshen Hu,Qian Pan,Danling Wang,Zhuohua Zhang,Zhuohua Zhang +8 more
TL;DR: The results suggest that ATP13A2 plays important roles in protecting cells against manganese cytotoxicity via regulating intracellularManganese homeostasis and provides a potential mechanism of KRS and parkinsonism pathogenesis.
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Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells
Shuiliang Wang,Jingcao Huang,Jingcao Huang,Hui Lyu,Choon-Kee Lee,Choon-Kee Lee,Jieqiong Tan,Juhong Wang,Bolin Liu +8 more
TL;DR: The data suggest that epigenetic regulation via miRNA-dependent or -independent mechanisms may represent a novel approach to treat breast cancer patients with erbB2-overexpressing tumors.